antigen processing and presentation of exogenous peptide antigen via MHC class II
proteolysis
neutrophil degranulation
lipoprotein catabolic process
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of establishment of protein localization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1509
13033
Ensembl
ENSG00000117984
ENSMUSG00000007891
UniProt
P07339
P18242
RefSeq (mRNA)
NM_001909
NM_009983
RefSeq (protein)
NP_001900
NP_034113
Location (UCSC)
Chr 11: 1.75 – 1.76 Mb
Chr 7: 141.93 – 141.94 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Cathepsin D is a protein that in humans is encoded by the CTSD gene.[5][6] This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes.[7] The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments.[8] This proteinase, which is a member of the peptidase A1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of the CTSD gene is initiated from several sites, including one that is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.[6] Homozygous deletion of the CTSD gene leads to early lethality in the postnatal phase.[9] Deficiency of CTSD gene has been reported an underlying cause of neuronal ceroid lipofuscinosis (NCL).[10]
^ abcGRCh38: Ensembl release 89: ENSG00000117984 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000007891 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Faust PL, Kornfeld S, Chirgwin JM (August 1985). "Cloning and sequence analysis of cDNA for human cathepsin D". Proceedings of the National Academy of Sciences of the United States of America. 82 (15): 4910–4. Bibcode:1985PNAS...82.4910F. doi:10.1073/pnas.82.15.4910. PMC 390467. PMID 3927292.
^ ab"Entrez Gene: CTSD cathepsin D".
^Barrett AJ (April 1970). "Cathepsin D. Purification of isoenzymes from human and chicken liver". The Biochemical Journal. 117 (3): 601–7. doi:10.1042/bj1170601. PMC 1178965. PMID 5419752.
^Diment S, Martin KJ, Stahl PD (August 1989). "Cleavage of parathyroid hormone in macrophage endosomes illustrates a novel pathway for intracellular processing of proteins". The Journal of Biological Chemistry. 264 (23): 13403–6. doi:10.1016/S0021-9258(18)80010-2. PMID 2760027.
^Saftig P, Hetman M, Schmahl W, Weber K, Heine L, Mossmann H, Köster A, Hess B, Evers M, von Figura K (August 1995). "Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells". The EMBO Journal. 14 (15): 3599–608. doi:10.1002/j.1460-2075.1995.tb00029.x. PMC 394433. PMID 7641679.
CathepsinD is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked...
turnover. Cathepsin A (serine protease) Cathepsin B (cysteine protease) Cathepsin C (cysteine protease) CathepsinD (aspartyl protease) Cathepsin E (aspartyl...
Cathepsin B belongs to a family of lysosomal cysteine proteases known as the cysteine cathepsins and plays an important role in intracellular proteolysis...
non-pepsin proteinase, cathepsinD-like acid proteinase, cathepsin E-like acid proteinase, cathepsinD-type proteinase) is an enzyme. Cathepsin E is a protease...
Cathepsin S is a protein that in humans is encoded by the CTSS gene. Transcript variants utilizing alternative polyadenylation signals exist for this...
protein's role in cathepsinD deficiency; the overexpression of the defective protein appears to have significant effects on cathepsinD processing, with...
Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. The protein encoded by this gene is a cysteine cathepsin, a lysosomal...
(2022-11-30). "Senile plaques in Alzheimer's disease arise from Aβ- and CathepsinD-enriched mixtures leaking out during intravascular haemolysis and microaneurysm...
Cathepsin C (CTSC) also known as dipeptidyl peptidase I (DPP-I) is a lysosomal exo-cysteine protease belonging to the peptidase C1 protein family, a subgroup...
Cathepsin G is a protein that in humans is encoded by the CTSG gene. It is one of the three serine proteases of the chymotrypsin family that are stored...
well known to be an inhibitor of aspartic proteases such as pepsin, cathepsinsD and E. Except for its role as a protease inhibitor, however, the pharmacological...
conversion of pepsinogen to pepsin under acidic conditions. BACE1, BACE2 CathepsinDCathepsin E Chymosin (or "rennin") Napsin-A Nepenthesin Pepsin Presenilin...
the activation of the kinase suppressor of Ras (KSR), PKCζ, and cathepsinD. CathepsinD has been proposed as the main target for ceramide formed in organelles...
(2022-11-30). "Senile plaques in Alzheimer's disease arise from Aβ- and cathepsinD-enriched mixtures leaking out during intravascular hemolysis and microaneurysm...
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. The protein is a cysteine cathepsin, a lysosomal cysteine protease that plays a...
Hentze, M.; Hasilik, A.; Figura, Kurt v. (1984). "Enhanced degradation of CathepsinD synthesized in the presence of the threonine analog beta-hydroxynorvaline"...
Several other cathepsins are expressed in osteoclasts including cathepsins B, C, D, E, G, and L. The function of these cysteine and aspartic proteases...
structures contain endocytic markers even small lysosomal proteins such as cathepsinD. The process is similar in yeast, however the gene names differ. For...
Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene. This gene encodes a...
Cathepsin H is a protein that in humans is encoded by the CTSH gene. The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease...
contain distinct aggregates of the secreted components glucosylceramide, cathepsinD, KLK7, KLK8 and corneodesmosin. Transportation of molecules via lamellar...
thioesterase is involved in CLN1. Acid protease is involved in CLN2. CathepsinD is involved in CLN10. DNA analysis can be used to help confirm the diagnosis...
Cathepsin F is a protein that in humans is encoded by the CTSF gene. Cysteine cathepsins are a family of cysteine proteases that represent a major component...
(2022-11-30). "Senile plaques in Alzheimer's disease arise from Aβ- and CathepsinD-enriched mixtures leaking out during intravascular haemolysis and microaneurysm...
Global Information
