CHST6 information

CHST6
Identifiers
Aliases	CHST6, MCDC1, carbohydrate sulfotransferase 6, GST4-beta, gn6st-5, hCGn6ST, glcNAc6ST-5, C-GlcNAc6ST
External IDs	OMIM: 605294; MGI: 1931825; HomoloGene: 56927; GeneCards: CHST6; OMA:CHST6 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	75,495,445 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	112,637,079 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; nasal epithelium; ; tibia; ; mucosa of paranasal sinus; ; olfactory zone of nasal mucosa; ; trachea; ; external globus pallidus; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; pars reticulata;
	Top expressed in
	vestibular sensory epithelium; ; utricle; ; trachea; ; cornea; ; iris; ; vestibular membrane of cochlear duct; ; trigeminal ganglion; ; lumbar spinal ganglion; ; stria vascularis; ; superior cervical ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	sulfotransferase activity; transferase activity; N-acetylglucosamine 6-O-sulfotransferase activity;
Cellular component	Golgi apparatus; Golgi membrane; membrane; integral component of membrane; trans-Golgi network;
Biological process	sulfur compound metabolic process; keratan sulfate biosynthetic process; N-acetylglucosamine metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4166
	56773
	ENSG00000183196
	ENSMUSG00000031952
	Q9GZX3
	Q9QUP4
	NM_021615
	NM_019950
	NP_067628
	NP_064334
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.^[5]^[6]^[7]

It codes for an enzyme necessary for the production of keratan sulfate. Mutations in the gene lead to macular corneal dystrophy.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183196 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031952 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vance JM, Jonasson F, Lennon F, Sarrica J, Damji KF, Stauffer J, Pericak-Vance MA, Klintworth GK (Jul 1996). "Linkage of a gene for macular corneal dystrophy to chromosome 16". Am J Hum Genet. 58 (4): 757–62. PMC 1914688. PMID 8644739.
^ Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (Nov 2000). "Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene". Nat Genet. 26 (2): 237–41. doi:10.1038/79987. PMID 11017086. S2CID 25547752.
^ "Entrez Gene: CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6".

and 6 Related for: CHST6 information