Class of enzymes which transfer a sulfo group (–SO3) between molecules
Sulfotransferase
Crystal Structure of Human Sulfotransferase SULT1A3 in Complex with Dopamine and 3-Phosphoadenosine 5-Phosphate
Identifiers
EC no.
2.8.2.-
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In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group (R−SO−3) from a donor molecule to an acceptor alcohol (R−OH) or amine (R−NH2).[1] The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R−OSO−3):
whereas an amine leads to a sulfamate (R−NH−SO−3):
Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.[2]
General structure of a sulfonic acid with the blue marked functional group
^Negishi M, Pedersen LG, Petrotchenko E, et al. (2001). "Structure and function of sulfotransferases". Arch. Biochem. Biophys. 390 (2): 149–57. doi:10.1006/abbi.2001.2368. PMID 11396917.
^Rath VL, Verdugo D, Hemmerich S (2004). "Sulfotransferase structural biology and inhibitor discovery". Drug Discov. Today. 9 (23): 1003–11. doi:10.1016/S1359-6446(04)03273-8. PMID 15574316.
In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group (R−SO−3) from a donor molecule to an acceptor...
Phenol sulfotransferase may refer to: SULT1A1, a human gene encoding a sulfotransferase SULT1A2, a human gene encoding a sulfotransferase SULT1A3, a human...
Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by...
In biochemistry, carbohydrate sulfotransferases are enzymes within the class of sulfotransferases which catalyze the transfer of the sulfate (−SO−3) functional...
In enzymology, an amine sulfotransferase (EC 2.8.2.3) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + an amine ⇌ {\displaystyle...
Sulfotransferase 1A1 is an enzyme that in humans is encoded by the SULT1A1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones...
Tyrosylprotein sulfotransferase is an enzyme that catalyzes tyrosine sulfation. Tyrosylprotein sulfotransferase is the enzyme that catalyzes the sulfation...
In enzymology, a scymnol sulfotransferase (EC 2.8.2.32) is an enzyme that catalyzes the chemical reaction 3'-Phosphoadenosine-5'-phosphosulfate + 5beta-scymnol...
Stf0 sulfotransferases are essential for the biosynthesis of sulfolipid-1 in prokaryotes. They adopt a structure that belongs to the sulfotransferase superfamily...
In enzymology, a desulfoglucosinolate sulfotransferase (EC 2.8.2.24) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + desulfoglucotropeolin...
In enzymology, a petromyzonol sulfotransferase (EC 2.8.2.31) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha...
In enzymology, a cortisol sulfotransferase (EC 2.8.2.18) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + cortisol ⇌ {\displaystyle...
In enzymology, a glycochenodeoxycholate sulfotransferase (EC 2.8.2.34) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate +...
Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many...
In enzymology, a psychosine sulfotransferase (EC 2.8.2.13) is an enzyme that catalyzes the chemical reaction: 3'-phosphoadenylyl sulfate + galactosylsphingosine...
Estrone sulfotransferase (EST) (EC 2.8.2.4), also known as estrogen sulfotransferase, is an enzyme that catalyzes the transformation of an unconjugated...
transferase, in short PST or SULT1, is a subfamily of the enzyme cytosolic sulfotransferases (SULTs) consisting of at least 8 isoforms in humans that catalyze...
Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene. Heparan sulfate proteoglycans are ubiquitous components...
In enzymology, a galactosylceramide sulfotransferase (EC 2.8.2.11) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + a galactosylceramide...
In enzymology, a thiol sulfotransferase (EC 2.8.2.16) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + a thiol ⇌ {\displaystyle...
Global Information
![{\displaystyle {\ce {R-SO3-}}\ +\ {\ce {R'-OH}}\quad {\xrightarrow[{\text{ SULT }}]{}}\quad {\ce {R-H}}\ +\ {\ce {R'-OSO3-}}}](https://wikimedia.org/api/rest_v1/media/math/render/svg/309f6adbd894014d72d03faf7b24c04b81e1f235)
![{\displaystyle {\ce {R-SO3-}}\ +\ {\ce {R'-NH2}}\quad {\xrightarrow[{\text{ SULT }}]{}}\quad {\ce {R-H}}\ +\ {\ce {R'-NHSO3-}}}](https://wikimedia.org/api/rest_v1/media/math/render/svg/b5606063c04db8ea36fe2dd0674ec64f45c93be9)
