Class of enzymes which transfer a sulfo group (–SO3) between molecules
Sulfotransferase
Crystal Structure of Human Sulfotransferase SULT1A3 in Complex with Dopamine and 3-Phosphoadenosine 5-Phosphate
Identifiers
EC no.
2.8.2.-
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In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group (R−SO−3) from a donor molecule to an acceptor alcohol (R−OH) or amine (R−NH2).[1] The most common sulfo group donor is 3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a sulfate (R−OSO−3):
whereas an amine leads to a sulfamate (R−NH−SO−3):
Both reactive groups for a sulfonation via sulfotransferases may be part of a protein, lipid, carbohydrate or steroid.[2]
General structure of a sulfonic acid with the blue marked functional group
^Negishi M, Pedersen LG, Petrotchenko E, et al. (2001). "Structure and function of sulfotransferases". Arch. Biochem. Biophys. 390 (2): 149–57. doi:10.1006/abbi.2001.2368. PMID 11396917.
^Rath VL, Verdugo D, Hemmerich S (2004). "Sulfotransferase structural biology and inhibitor discovery". Drug Discov. Today. 9 (23): 1003–11. doi:10.1016/S1359-6446(04)03273-8. PMID 15574316.
In biochemistry, sulfotransferases (SULTs) are transferase enzymes that catalyze the transfer of a sulfo group (R−SO−3) from a donor molecule to an acceptor...
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Sulfotransferase 1A1 is an enzyme that in humans is encoded by the SULT1A1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones...
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In enzymology, a galactosylceramide sulfotransferase (EC 2.8.2.11) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + a galactosylceramide...
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transferase, in short PST or SULT1, is a subfamily of the enzyme cytosolic sulfotransferases (SULTs) consisting of at least 8 isoforms in humans that catalyze...
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Heparan sulfate 6-O-sulfotransferase 2 is a protein that in humans is encoded by the HS6ST2 gene. Heparan sulfate proteoglycans are ubiquitous components...
In enzymology, a thiol sulfotransferase (EC 2.8.2.16) is an enzyme that catalyzes the chemical reaction 3'-phosphoadenylyl sulfate + a thiol ⇌ {\displaystyle...
of an electrocardiogram connecting the QRS complex and the T wave Sulfotransferase, enzymes that catalyze the transfer of a sulfo group Heat-stable enterotoxin...
Global Information
![{\displaystyle {\ce {R-SO3-}}\ +\ {\ce {R'-OH}}\quad {\xrightarrow[{\text{ SULT }}]{}}\quad {\ce {R-H}}\ +\ {\ce {R'-OSO3-}}}](https://wikimedia.org/api/rest_v1/media/math/render/svg/309f6adbd894014d72d03faf7b24c04b81e1f235)
![{\displaystyle {\ce {R-SO3-}}\ +\ {\ce {R'-NH2}}\quad {\xrightarrow[{\text{ SULT }}]{}}\quad {\ce {R-H}}\ +\ {\ce {R'-NHSO3-}}}](https://wikimedia.org/api/rest_v1/media/math/render/svg/b5606063c04db8ea36fe2dd0674ec64f45c93be9)
