LSP1 information

LSP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BH8, 4NO0, 4NO2
Identifiers
Aliases	LSP1, WP34, pp52, lymphocyte-specific protein 1, lymphocyte specific protein 1
External IDs	OMIM: 153432; MGI: 96832; HomoloGene: 1750; GeneCards: LSP1; OMA:LSP1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,892,267 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	142,048,604 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; spleen; ; appendix; ; bone marrow cells; ; right adrenal cortex; ; lymph node; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	granulocyte; ; thymus; ; mesenteric lymph nodes; ; tibiofemoral joint; ; vas deferens; ; spleen; ; uterus; ; lip; ; efferent ductule; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; signal transducer activity;
Cellular component	extracellular exosome; actin cytoskeleton; membrane; plasma membrane;
Biological process	chemotaxis; cellular defense response; defense response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4046
	16985
	ENSG00000130592; ENSG00000288199
	ENSMUSG00000018819
	P33241
	P19973
NM_002339; NM_001013253; NM_001013254; NM_001013255; NM_001242932;
	NM_001289005
NM_001136071; NM_001271508; NM_001271509; NM_001271510; NM_001271523;
	NM_019391
NP_001013271; NP_001013272; NP_001013273; NP_001229861; NP_001275934;
	NP_002330
NP_001129543; NP_001258437; NP_001258438; NP_001258439; NP_001258452;
	NP_062264
	Wikidata
View/Edit Human	View/Edit Mouse

Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene.^[5]^[6]

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

^ ^a ^b ^c ENSG00000288199 GRCh38: Ensembl release 89: ENSG00000130592, ENSG00000288199 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018819 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kadiyala RK, McIntyre BW, Krensky AM (Jan 1991). "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen". Eur J Immunol. 20 (11): 2417–23. doi:10.1002/eji.1830201109. PMID 2174784. S2CID 35829868.
^ ^a ^b "Entrez Gene: LSP1 lymphocyte-specific protein 1".

[refGRCh38Ensembl-1] ENSG00000288199 GRCh38: Ensembl release 89: ENSG00000130592, ENSG00000288199 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018819 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2174784-5] Kadiyala RK, McIntyre BW, Krensky AM (Jan 1991). "Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen". Eur J Immunol. 20 (11): 2417–23. doi:10.1002/eji.1830201109. PMID 2174784. S2CID 35829868.

[entrez-6] "Entrez Gene: LSP1 lymphocyte-specific protein 1".

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