Normal histology of the breast, with myoepithelial cell annotated near bottom right.
Details
Identifiers
Latin
myoepitheliocytus
TH
H2.00.02.0.03059
FMA
67799 67805, 67799
Anatomical terminology
[edit on Wikidata]
Myoepithelial cells (sometimes referred to as myoepithelium) are cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells. These may be positive for alpha smooth muscle actin and can contract and expel the secretions of exocrine glands. They are found in the sweat glands, mammary glands, lacrimal glands, and salivary glands. Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. In the case of wound healing, myoepithelial cells reactively proliferate. Presence of myoepithelial cells in a hyperplastic tissue proves the benignity of the gland and, when absent, indicates cancer. Only rare cancers like adenoid cystic carcinomas contains myoepithelial cells as one of the malignant components.
It can be found in endoderm or ectoderm.[1]
^Jules J. Berman (2009). Neoplasms: principles of development and diversity. Jones & Bartlett Learning. pp. 207–. ISBN 978-0-7637-5570-6. Retrieved 16 April 2010.
and 27 Related for: Myoepithelial cell information
Myoepithelialcells (sometimes referred to as myoepithelium) are cells usually found in glandular epithelium as a thin layer above the basement membrane...
large), which are lined with milk-secreting cuboidal cells and surrounded by myoepithelialcells. These alveoli join to form groups known as lobules....
contractile myoepithelialcells that function to facilitate excretion of secretory product. The secretory activities of the gland cells and the contractions...
structure—these cells aid mucin assembly. Furthermore, unlike other exocrine glands, the pancreas does not have myoepithelialcells around the ducts. Ductal cells have...
Human Cell Atlas project, which started in 2016, had as one of its goals to "catalog all cell types (for example, immune cells or brain cells) and sub-types...
and myoepithelialcell types of the gland and have been shown to have the ability to regenerate the entire organ in mice. Intestinal stem cells divide...
bloodstream, oxytocin makes its way to myoepithelialcells, which lie between the extracellular matrix and luminal epithelial cells that also make up the alveoli...
epithelial cells. The epithelial cells are interposed by the myoepithelialcells. Myoepithelialcells support the secretory epithelial cells. The duct...
Lactiferous ducts are lined by a columnar epithelium supported by myoepithelialcells. Prior to 2005, it was thought within the areola the lactiferous...
epithelial cells which line the papillae. These cells, which are not myoepithelialcells, have been termed globoid cells. They have eosinophilic cytoplasm (i.e...
oxytocin release, which, when in the peripheral bloodstream, causes myoepithelialcell contraction and lactation: this is an example of a non-nerve-innervation...
simple duct widening. In addition to nonspecific duct widening the myoepithelialcell layer is atrophic, missing or replaced by fibrous tissue. The original...
that merocrine secretion takes place. Myoepithelialcells form a smooth muscle lining around the secretory cells; when the muscles contract, they squeeze...
and the growth-inhibitory signals that it produces in malignant myoepithelialcells begs for further investigation with regard to cancer research. Therefore...
the breast wherein cells look very similar to normal. It is a spectrum of changes that can range from minimal stratification of cells to proliferations...
coelomic myoepithelialcells in amphioxus (Branchiostoma) may have significance in renal function. Located along the coelom, myoepithelialcells have both...
pulsatile manner, via stimulation of the vagus nerve. This causes myoepithelialcells, which surround the mammary alveoli, to contract. Oxytocin injections...
for calponin in ductal carcinoma in situ, highlighting myoepithelialcells around all tumor cells, thereby ruling out invasive ductal carcinoma. Ductal...
modified contractile cells called myoepithelialcells. These cells are stimulated by the sympathetic nervous system. When stimulated, the cells contract, widening...
and is thought to be caused by autonomic dysfunction of salivary myoepithelialcells. Unger, J. M.; Chintapalli, K. N. (1983). "Computed tomography of...
Myoepithelial carcinoma, and they account for 1% of the salivary tumors with poor prognosis. As the name suggests, it consists of myoepithelialcells...
or myxoid stroma enveloping benign bland appearing epithelial and myoepithelialcells. Its malignant counterpart is malignant chondroid syringoma. "Chondroid...
by well-developed myoepithelialcells and a sparse, vascular stroma. Each acinus consists of a grape-like mass of lacrimal gland cells with their apices...
characterised by neoplastic proliferation of epithelial (ductal) cells along with myoepithelial components, having a malignant potentiality. It is the most...
lumen, lined by myoepithelialcells. The pharynx opens into a cylindrical intestine, which is lined with glandular and digestive cells. The anus is located...
is similar to that of myoepithelial sialadenitis. In general, a diffuse to multinodular expansion is observed in myoepithelial sialadenitis. A distinguishing...
somatic cells are mainly lactocytes and myoepithelialcells derived from the mother's mammary glands. The stem cells found in human breast milk have been...
Global Information