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Calcium pumps are a family of ion transporters found in the cell membrane of all animal cells. They are responsible for the active transport of calcium out of the cell for the maintenance of the steep Ca2+ electrochemical gradient across the cell membrane. Calcium pumps play a crucial role in proper cell signalling by keeping the intracellular calcium concentration roughly 10,000 times lower than the extracellular concentration.[1] Failure to do so is one cause of muscle cramps.
The plasma membrane Ca2+ ATPase and the sodium-calcium exchanger are together the main regulators of cytoplasmic Ca2+ concentrations.[2]
^Carafoli E (January 1991). "Calcium pump of the plasma membrane". Physiol. Rev. 71 (1): 129–53. doi:10.1152/physrev.1991.71.1.129. PMID 1986387.
^Strehler EE, Zacharias DA (January 2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps". Physiol. Rev. 81 (1): 21–50. doi:10.1152/physrev.2001.81.1.21. PMID 11152753. S2CID 9062253.
Calciumpumps are a family of ion transporters found in the cell membrane of all animal cells. They are responsible for the active transport of calcium...
thus it is necessary for the cell to employ ion pumps to remove the Ca2+. The PMCA and the sodium calcium exchanger (NCX) are together the main regulators...
When 2 calcium ions, along with a molecule of ATP, bind to the cytosolic side of the pump (i.e. the region of the pump outside the SR), the pump opens...
its original conformation. P-type ATPase: sodium potassium pump, calciumpump, proton pump F-ATPase: mitochondrial ATP synthase, chloroplast ATP synthase...
with the transport of calcium out of the cell. In addition, the plasma membrane Ca2+ ATPase (PMCA) obtains energy to pumpcalcium out of the cell by hydrolysing...
Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium (Ca2+...
the calcium channel TRPV6, to the basolateral side, where calciumpumps such as PMCA1 utilize intracellular adenosine triphosphate to pumpcalcium into...
(soft-tissue pump), as well as the cycling of calcium carbonate (CaCO3) formed into shells by certain organisms such as plankton and mollusks (carbonate pump). Budget...
Plasma membrane calcium-transporting ATPase 1 also known as Plasma membrane calciumpump isoform 1 is a plasma membrane Ca2+ ATPase, an enzyme that in...
calcium ions and pumps them out into the sarcoplasm when the muscle fiber is stimulated. After their release from the sarcoplasmic reticulum, calcium...
charge of +1 entering the cell). This calcium is then pumped back into the cell and back into the SR via calciumpumps (including the SERCA). This phase consists...
Calcium metabolism is the movement and regulation of calcium ions (Ca2+) in (via the gut) and out (via the gut and kidneys) of the body, and between body...
A peristaltic pump, also commonly known as a roller pump, is a type of positive displacement pump used for pumping a variety of fluids. The fluid is contained...
Aldgate Pump is a historic former water pump located at the junction where Aldgate High Street meets Fenchurch Street and Leadenhall Street in the City...
it inhibits the calciumpumps that pumpcalcium back into the sarcoplasmic reticulum. When it's phosphorylated by PKA, levels of calcium stored in the sarcoplasmic...
transport by SR calciumpumps, the storage of calcium in the SR by acidic lumenal proteins and the release of calcium from the SR by calcium release channels...
the cell as a membrane containing a number of pumps such as the sodium potassium pump and the calciumpump and channels that engage in active transport...
Calcium signaling is the use of calcium ions (Ca2+) to communicate and drive intracellular processes often as a step in signal transduction. Ca2+ is important...
muscles contract, Calcium ions are released from the sarcoplasmic reticulum by release channels. These channels close and calciumpumps open to relax muscles...
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) also known as Calciumpump 1, is an enzyme that in humans is encoded by the ATP2A1 gene. This...
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