Small RNAs (sRNAs) have been identified within the C. elegans genome and comparative genomics has shown that they are conserved across several nematode species. These sRNAs contain a characteristic 2,2,7-trimethylguanosine (TMG) cap structure that identifies them as non-coding RNAs that have a functional role within the cell but at present the exact function of these sRNAs is unknown. Immunoprecipitation using antibodies against TMG and RNA microarrays were used to identify these sRNA.[1]
^Jia, D.; Cai, L.; He, H.; Skogerbø, G.; Li, T.; Aftab, N.; Chen, R. (September 2007). "Systematic identification of non-coding RNA 2,2,7-trimethylguanosine cap structures in Caenorhabditis elegans". BMC Molecular Biology. 8: 86. doi:10.1186/1471-2199-8-86. PMC 2200864. PMID 17903271.
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SmallRNAs (sRNAs) have been identified within the C. elegans genome and comparative genomics has shown that they are conserved across several nematode...
(rod-like) and Latin elegans (elegant). In 1900, Maupas initially named it Rhabditides elegans. Osche placed it in the subgenus Caenorhabditis in 1952, and in...
expression in the nematode, Caenorhabditiselegans. They won the Nobel prize for their research with RNAi in 2006. siRNAs and their role in post-transcriptional...
The nematode worm Caenorhabditiselegans was first studied in the laboratory by Victor Nigon and Ellsworth Dougherty in the 1940s, but came to prominence...
Lee RC, Ambros V (October 2001). "An extensive class of smallRNAs in Caenorhabditiselegans". Science. 294 (5543): 862–4. Bibcode:2001Sci...294..862L...
Physiology or Medicine for their work on RNAi in the nematode worm Caenorhabditiselegans, which they published in 1998. Since the discovery of RNAi and its...
C. elegans which identified 18 novel miRNA genes as well as a new class of nematode smallRNAs termed 21U-RNAs. Another study comparing smallRNA profiles...
RNA silencing or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated by non-coding RNAs such...
Zucker-Aprison E, Blumenthal T (May 1990). "The spliceosomal snRNAs of Caenorhabditiselegans". Nucleic Acids Research. 18 (9): 2633–42. doi:10.1093/nar/18...
"Potent and specific genetic interference by double-stranded RNA in Caenorhabditiselegans". Nature. 391 (6669): 806–11. Bibcode:1998Natur.391..806F. doi:10...
Zucker-Aprison E, Blumenthal T (May 1990). "The spliceosomal snRNAs of Caenorhabditiselegans". Nucleic Acids Research. 18 (9): 2633–42. doi:10.1093/nar/18...
"Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. Elegans developmental timing". Cell. 106...
sbRNA (stem-bulge RNA) is a family of non-coding RNA first discovered in Caenorhabditiselegans. It was identified during a full transcriptome screen...
The nematode Caenorhabditiselegans is often used as a model organism for studying aging at the molecular level. For example, in C. elegans aging negatively...
Caenorhabditis briggsae is a small nematode, closely related to Caenorhabditiselegans. The differences between the two species are subtle. The male tail...
especially large ganglion at the front, called the brain. The nematode Caenorhabditiselegans has been studied because of its importance in genetics. In the early...
separable functions of Y RNAs. Although Y RNA-derived smallRNAs are similar in size to microRNAs, it has been shown that these Y RNA fragments are not involved...
of smallRNAs located in intergenic regions of its genome. The presence of at least 55 of these has been verified experimentally. 275 potential sRNA-encoding...
melanogaster and Caenorhabditiselegans. The number of mirtrons identified to date are 14, 9, and 19 in D. melanogaster, C. elegans and mammals respectively...
Orsay virus is a positive-sense single-stranded RNA virus that infects Caenorhabditiselegans nematode. It resembles nodaviruses (family Nodaviridae)...
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