CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling.[1][2] Due to their dynamic role within the ECM they are considered matricellular proteins.[3][4][5]
^Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nat Rev Drug Discov. 10 (12): 945–63. doi:10.1038/nrd3599. PMC 3663145. PMID 22129992.
^Kular L, Pakradouni J, Kitabgi P, Laurent M, Martinerie C (March 2011). "The CCN family: a new class of inflammation modulators?". Biochimie. 93 (3): 377–88. doi:10.1016/j.biochi.2010.11.010. PMID 21130134.
^Chen CC, Lau LF (April 2009). "Functions and mechanisms of action of CCN matricellular proteins". Int. J. Biochem. Cell Biol. 41 (4): 771–83. doi:10.1016/j.biocel.2008.07.025. PMC 2668982. PMID 18775791.
^Holbourn KP, Acharya KR, Perbal B (October 2008). "The CCN family of proteins: structure-function relationships". Trends Biochem. Sci. 33 (10): 461–73. doi:10.1016/j.tibs.2008.07.006. PMC 2683937. PMID 18789696.
^Leask A, Abraham DJ (December 2006). "All in the CCN family: essential matricellular signaling modulators emerge from the bunker". J. Cell Sci. 119 (Pt 23): 4803–10. doi:10.1242/jcs.03270. PMID 17130294.
CCNproteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling. Due to their dynamic role within the...
NOV, the first three proteins identified that belong to the "CCN" protein family - also see CCN intercellular signaling protein Critical care nursing...
matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has...
Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. CYR61...
Examples of matricellular proteins include the CCN family of proteins (also known as CCN intercellular signaling protein), fibulins, osteopontin, periostin...
CCN1 may refer to: Cyclin A2 - a protein in the cyclin family CYR61 - a protein in the CCN family This disambiguation page lists articles associated with...
A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that...
targeting cancerous cells for apoptosis, as well as in understanding how proteins interact with DNA. Many characterized crosslinking agents have two independently...
intelligence (AI) that started in the late 2010s. Known examples include protein folding prediction led by Google DeepMind and generative AI led by OpenAI...
RNA codon table, because when proteins are made in a cell by ribosomes, it is messenger RNA (mRNA) that directs protein synthesis. The mRNA sequence is...
for use in the textile industry but are now commonly used for staining proteins in analytical biochemistry. Coomassie brilliant blue G-250 differs from...
Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. It contains an α-amino group (which is in the protonated −NH+3 form when...
by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 appear in the genetic code of life. Amino acids can be classified...
mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K)...
can bind to antibody proteins or T-cell receptors, triggering an immune system response. The tumor antigens are often proteins or other macromolecules...
throat infection and tiredness. Venetoclax attaches to a protein called Bcl-2. This protein is present in high amounts in CLL cancer cells, where it helps...
point 94.5 to 95 °C (202.1 to 203.0 °F) SMILES O=C(N)C(c1ncccc1)(c2ccccc2)CCN(C(C)C)C(C)C InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25...
cause only a synonymous mutation, or an error that would not affect the protein because the hydrophilicity or hydrophobicity is maintained by equivalent...
aquaculture is expected to use more of these more environmentally-friendly protein sources, so supplementation would become more important. The need of taurine...
and form aerosols that are proposed to serve as cloud condensation nuclei (CCN). Such aerosols can increase the brightness of clouds and cool the climate...
that block the action of proteasomes, cellular complexes that break down proteins. They are being studied in the treatment of cancer; three are approved...
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