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CCN protein information


CCN proteins are a family of extracellular matrix (ECM)-associated proteins involved in intercellular signaling.[1][2] Due to their dynamic role within the ECM they are considered matricellular proteins.[3][4][5]

  1. ^ Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nat Rev Drug Discov. 10 (12): 945–63. doi:10.1038/nrd3599. PMC 3663145. PMID 22129992.
  2. ^ Kular L, Pakradouni J, Kitabgi P, Laurent M, Martinerie C (March 2011). "The CCN family: a new class of inflammation modulators?". Biochimie. 93 (3): 377–88. doi:10.1016/j.biochi.2010.11.010. PMID 21130134.
  3. ^ Chen CC, Lau LF (April 2009). "Functions and mechanisms of action of CCN matricellular proteins". Int. J. Biochem. Cell Biol. 41 (4): 771–83. doi:10.1016/j.biocel.2008.07.025. PMC 2668982. PMID 18775791.
  4. ^ Holbourn KP, Acharya KR, Perbal B (October 2008). "The CCN family of proteins: structure-function relationships". Trends Biochem. Sci. 33 (10): 461–73. doi:10.1016/j.tibs.2008.07.006. PMC 2683937. PMID 18789696.
  5. ^ Leask A, Abraham DJ (December 2006). "All in the CCN family: essential matricellular signaling modulators emerge from the bunker". J. Cell Sci. 119 (Pt 23): 4803–10. doi:10.1242/jcs.03270. PMID 17130294.

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3D model (JSmol) Interactive image SMILES [Gd+3].[O-]C(=O)CN(CC(=O)NC)CCN(CCN(CC([O-])=O)CC(=O)NC)CC([O-])=O InChI InChI=1S/C16H29N5O8...

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