regulation of ER to Golgi vesicle-mediated transport
regulation of protein ubiquitination
protein polyubiquitination
regulation of protein processing
positive regulation of ubiquitin-dependent protein catabolic process
protein destabilization
protein ubiquitination
negative regulation of cell population proliferation
proteasome-mediated ubiquitin-dependent protein catabolic process
endoplasmic reticulum mannose trimming
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
11236
75841
Ensembl
ENSG00000170881
ENSMUSG00000037075
UniProt
Q8WU17
Q7TMV1
RefSeq (mRNA)
NM_007218
NM_175226
RefSeq (protein)
NP_009149
NP_780435
Location (UCSC)
Chr 8: 124.47 – 124.49 Mb
Chr 15: 58.76 – 58.78 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
RING finger protein 139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene.[5][6]
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medullary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP].[6]
^ abcGRCh38: Ensembl release 89: ENSG00000170881 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037075 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI, Li F, Drabkin HA (Sep 1998). "The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8". Proc Natl Acad Sci U S A. 95 (16): 9572–7. Bibcode:1998PNAS...95.9572G. doi:10.1073/pnas.95.16.9572. PMC 21380. PMID 9689122.
^ ab"Entrez Gene: RNF139 ring finger protein 139".
139, also known as TRC8, is a protein that in humans is encoded by the RNF139 gene. The protein encoded by this gene is a multi-membrane spanning protein...
potential etiology is the dysfunctioning of the tumor suppressor gene, TRC8/RNF139, or even karyotypic abnormalities after close molecular examination. OGCT...