CD81 information

CD81
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G8Q, 1IV5, 3X0E, 5DFW, 5DFV
Identifiers
Aliases	CD81, CVID6, S5.7, TAPA1, TSPAN28, CD81 molecule
External IDs	OMIM: 186845; MGI: 1096398; HomoloGene: 20915; GeneCards: CD81; OMA:CD81 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	2,397,397 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	142,621,671 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; seminal vesicula; ; body of uterus; ; right coronary artery; ; canal of the cervix; ; right uterine tube; ; Descending thoracic aorta; ; left uterine tube; ; ascending aorta; ; apex of heart;
	Top expressed in
	aortic valve; ; ascending aorta; ; anterior horn of spinal cord; ; Epithelium of choroid plexus; ; efferent ductule; ; dentate gyrus of hippocampal formation granule cell; ; molar; ; optic nerve; ; external carotid artery; ; choroid plexus of fourth ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; MHC class II protein complex binding; transferrin receptor binding; virus receptor activity; integrin binding; cholesterol binding; lipid binding;
Cellular component	integral component of membrane; vesicle; membrane; focal adhesion; integral component of plasma membrane; immunological synapse; extracellular exosome; plasma membrane; basolateral plasma membrane;
Biological process	positive regulation of 1-phosphatidylinositol 4-kinase activity; protein localization; regulation of protein stability; receptor internalization; cellular response to low-density lipoprotein particle stimulus; regulation of cell motility; receptor-mediated virion attachment to host cell; protein localization to lysosome; cell surface receptor signaling pathway; positive regulation of B cell proliferation; positive regulation of cell population proliferation; regulation of immune response; positive regulation of peptidyl-tyrosine phosphorylation; viral entry into host cell; positive regulation of protein catabolic process in the vacuole; cell population proliferation; viral process; positive regulation of transcription by RNA polymerase II; regulation of complement activation; humoral immune response mediated by circulating immunoglobulin; protein localization to plasma membrane; adaptive immune response; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	975
	12520
	ENSG00000110651
	ENSMUSG00000037706
	P60033
	P35762
	NM_001297649; NM_004356
	NM_133655
	NP_001284578; NP_004347
	NP_598416
	Wikidata
View/Edit Human	View/Edit Mouse

CD81 molecule, also known as CD81 (Cluster of Differentiation 81), is a protein which in humans is encoded by the CD81 gene.^[5]^[6] It is also known as 26 kDa cell surface protein, TAPA-1 (Target of the Antiproliferative Antibody 1), and Tetraspanin-28 (Tspan-28).

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110651 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037706 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD81 CD81 molecule".
^ Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". Journal of Immunology. 147 (3): 1030–6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385. S2CID 31032048.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110651 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037706 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD81 CD81 molecule".

[pmid1650385-6] Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". Journal of Immunology. 147 (3): 1030–6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385. S2CID 31032048.

CD81 information

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