Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Identifiers
Symbol
FCGR3A
Alt. symbols
FCGR3, FCG3
NCBI gene
2214
HGNC
3619
OMIM
146740
RefSeq
NM_000569
UniProt
P08637
Other data
Locus
Chr. 1 q23
Search for
Structures
Swiss-model
Domains
InterPro
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Identifiers
Symbol
FCGR3B
Alt. symbols
FCGR3, FCG3
NCBI gene
2215
HGNC
3620
OMIM
610665
RefSeq
NM_000570
UniProt
O75015
Other data
Locus
Chr. 1 q23
Search for
Structures
Swiss-model
Domains
InterPro
CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages, and certain T cells.[1][2] CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction.[3] The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC).[4] It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16.
^Janeway C (2001). "Appendix II. CD antigens". Immunobiology (5 ed.). New York: Garland. ISBN 978-0-8153-3642-6.
^Georg P, et al. (2021). "Complement activation induces excessive T cell cytotoxicity in severe COVID-19". Cell. 185 (3): 493–512.e25. doi:10.1016/j.cell.2021.12.040. PMC 8712270. PMID 35032429.
^Vivier E, Morin P, O'Brien C, Druker B, Schlossman SF, Anderson P (January 1991). "Tyrosine phosphorylation of the Fc gamma RIII(CD16): zeta complex in human natural killer cells. Induction by antibody-dependent cytotoxicity but not by natural killing". Journal of Immunology. 146 (1): 206–10. doi:10.4049/jimmunol.146.1.206. PMID 1701792.
^Mandelboim O, Malik P, Davis DM, Jo CH, Boyson JE, Strominger JL (May 1999). "Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity". Proceedings of the National Academy of Sciences of the United States of America. 96 (10): 5640–4. Bibcode:1999PNAS...96.5640M. doi:10.1073/pnas.96.10.5640. PMC 21913. PMID 10318937.
CD16, also known as FcγRIII, is a cluster of differentiation molecule found on the surface of natural killer cells, neutrophils, monocytes, macrophages...
(CD14++ CD16− monocyte) The non-classical monocyte shows low level expression of CD14 and additional co-expression of the CD16 receptor (CD14+CD16++ monocyte)...
characterized by their cell killing ability. CD56dim NK cells are always CD16 positive (CD16 is the key mediator of antibody-dependent cellular cytotoxicity,...
is bound to the surface of a pathogen-infected target cell and is called CD16 or FcγRIII. Activation of FcγRIII by IgG causes the release of cytokines...
afrikanischer Völker CD14+15. Kinski und Ensemble: Shakespeare I Hamlet CD16+17. Kinski und Ensemble: Shakespeare II: Romeo und Julia CD18+19. Kinski...
Manley T, Ritz J, Schlossman SF (March 1990). "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer...
killer T cells can share other features with NK cells, as well, such as CD16 and CD56 expression and granzyme production. Invariant natural killer T (iNKT)...
killer cells Lysis of virally infected cells and tumour cells 7% (2–13%) CD16 CD56 but not CD3 T helper cells Release cytokines and growth factors that...
The Prestige Recordings is a box set by jazz musician John Coltrane. In review for AllMusic Lindsay Planer wrote: "The 16 CDs in this compendium represent...
Antibody with High Affinity and Specificity for Bst1/CD157 Antigen and Enhanced CD16 Binding". 56th ASH Annual Meeting and Exposition, S. Francisco (CA). 124:...
biopsy, i.e. biopsy from blood, which analyzes activated macrophages (CD14+/CD16+) for disease-specific epitopes, such as tumor cell components. Macrophages...
bites. The bite sites are infiltrated with T helper cells, CD8+ T cells, and CD16+ NK cells. In this mixture of infiltrates, most of the cells exhibiting EBV...
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