The Randle cycle, also known as the glucose fatty-acid cycle, is a metabolic process involving the competition of glucose and fatty acids for substrates.[1] It is theorized to play a role in explaining type 2 diabetes and insulin resistance.[2][3]
It was named for Philip Randle, who described it in 1963.[4]
^Bevilacqua S, Buzzigoli G, Bonadonna R, et al. (1990). "Operation of Randle's cycle in patients with NIDDM". Diabetes. 39 (3): 383–9. doi:10.2337/diabetes.39.3.383. PMID 2307295.
^Shuldiner AR, McLenithan JC (2004). "Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again". J. Clin. Invest. 114 (10): 1414–7. doi:10.1172/JCI23586. PMC 525752. PMID 15545992.
^Delarue J, Magnan C (2007). "Free fatty acids and insulin resistance". Current Opinion in Clinical Nutrition and Metabolic Care. 10 (2): 142–8. doi:10.1097/MCO.0b013e328042ba90. PMID 17285001. S2CID 9620797.
^Randle PJ, Garland PB, Hales CN, Newsholme EA (1963). "The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus". Lancet. 1 (7285): 785–9. doi:10.1016/S0140-6736(63)91500-9. PMID 13990765.
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