positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
cell adhesion
regulation of immune response
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of Fc receptor mediated stimulatory signaling pathway
cell recognition
cytokine production
positive regulation of immunoglobulin mediated immune response
signal transduction
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of mast cell activation
positive regulation of interferon-gamma production
positive regulation of natural killer cell cytokine production
positive regulation of T cell receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10666
225825
Ensembl
ENSG00000150637
ENSMUSG00000034028
UniProt
Q15762
Q8K4F0
RefSeq (mRNA)
NM_001303618 NM_001303619 NM_006566
NM_001039148 NM_001039149 NM_178687
RefSeq (protein)
NP_001290547 NP_001290548 NP_006557
NP_001034238 NP_848802
Location (UCSC)
Chr 18: 69.83 – 69.96 Mb
Chr 18: 89.2 – 89.29 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')[5] or DNAM-1 (DNAX Accessory Molecule-1)[5] is a ~65 kDa immunoglobulin-like transmembrane glycoprotein expressed on the surface of natural killer cells, NK T cell, B cells, dendritic cells, hematopoietic precursor cells, platelets, monocytes and T cells.[6]
DNAM-1 gene CD226 is conserved between human and mice. In humans the CD226 gene is located on chromosome 18q22.3.[7] In mice the CD226 gene is located on chromosome 18E4.
^ abcGRCh38: Ensembl release 89: ENSG00000150637 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000034028 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abFuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
^Huang Z, Qi G, Miller JS, Zheng SG (2020-07-24). "CD226: An Emerging Role in Immunologic Diseases". Frontiers in Cell and Developmental Biology. 8: 564. doi:10.3389/fcell.2020.00564. PMC 7396508. PMID 32850777.
CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') or DNAM-1 (DNAX Accessory Molecule-1) is a ~65...
is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1). The protein encoded by this gene belongs to the...
The Best of Blancmange (1996) is a compilation of singles, album and non album tracks from the English musical group Blancmange All songs written by Neil...
via LFA1 and MAC1 is promoted and enhanced by additional signals such as CD226-ligand and CD96-CD155 interactions. Lytic granules are secretory organelles...
Global Information
