Gadodiamide information

Gadodiamide
Clinical data
Trade names	Omniscan
Other names	2-[bis[2-(carboxylatomethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetate; gadolinium(+3) cation
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	US DailyMed: Gadodiamide;
Routes of; administration	Intravenous
ATC code	V08CA03 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: WARNINGRx-only; EU: Rx-only;
Pharmacokinetic data
Protein binding	negligible
Metabolism	not metabolized
Elimination half-life	77.8 minutes
Excretion	Kidney
Identifiers
	IUPAC name gadolinium(III) 5,8-bis(carboxylatomethyl)-2-[2-(methylamino)-2-oxoethyl]-10-oxo-2,5,8,11-tetraazadodecane-1-carboxylate hydrate;
CAS Number	131410-48-5 ; 122795-43-1 (hydrate);
PubChem CID	153921;
DrugBank	DB00225 ;
ChemSpider	135661 ;
UNII	84F6U3J2R6;
KEGG	D01645 ;
ChEBI	CHEBI:37333 ;
ChEMBL	ChEMBL1200346 ;
CompTox Dashboard (EPA)	DTXSID9048647 ;
Chemical and physical data
Formula	C16H28GdN5O9
Molar mass	591.68 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Gd+3].[O-]C(=O)CN(CC(=O)NC)CCN(CCN(CC([O-])=O)CC(=O)NC)CC([O-])=O;
	InChI InChI=1S/C16H29N5O8.Gd/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);/q;+3/p-3 ; Key:HZHFFEYYPYZMNU-UHFFFAOYSA-K ;
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Gadodiamide, sold under the brand name Omniscan, is a gadolinium-based MRI contrast agent (GBCA), used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
^ "Omniscan- gadodiamide injection". DailyMed. Retrieved 29 August 2021.
^ "Active substance: gadodiamide" (PDF). List of nationally authorised medicinal products. European Medicine Agency. 14 January 2021.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

[2] "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.

[Omniscan_FDA_label-3] "Omniscan- gadodiamide injection". DailyMed. Retrieved 29 August 2021.

[4] "Active substance: gadodiamide" (PDF). List of nationally authorised medicinal products. European Medicine Agency. 14 January 2021.

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