CCL18 information

CCL18
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4MHE
Identifiers
Aliases	CCL18, chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated), AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18, C-C motif chemokine ligand 18
External IDs	OMIM: 603757; HomoloGene: 48154; GeneCards: CCL18; OMA:CCL18 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,072,032 bp
RNA expression pattern
	Top expressed in
	lymph node; ; upper lobe of left lung; ; appendix; ; rectum; ; right lung; ; duodenum; ; spleen; ; gallbladder; ; right coronary artery; ; left coronary artery;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; CCR chemokine receptor binding; chemokine activity;
Cellular component	extracellular region; extracellular space;
Biological process	G protein-coupled receptor signaling pathway; monocyte chemotaxis; chemokine-mediated signaling pathway; cellular response to tumor necrosis factor; cell-cell signaling; neutrophil chemotaxis; chemotaxis; cell communication; positive regulation of GTPase activity; cellular response to interleukin-1; immune response; positive regulation of ERK1 and ERK2 cascade; cellular response to interferon-gamma; lymphocyte chemotaxis; inflammatory response; signal transduction; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; positive regulation of inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	6362
	n/a
	ENSG00000275385; ENSG00000278167; ENSG00000278006
	n/a
	P55774
	n/a
	NM_002988
	n/a
	NP_002979
	n/a
	Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family. The functions of CCL18 have been well studied in laboratory settings, however the physiological effects of the molecule in living organisms have been difficult to characterize because there is no similar protein in rodents that can be studied. The receptor for CCL18 has been identified in humans only recently, which will help scientists understand the molecule's role in the body.

CCL18 is produced and secreted mainly by innate immune system, and has effects mainly on the adaptive immune system. It was previously known as Pulmonary and activation-regulated chemokine (PARC), dendritic cell (DC)-chemokine 1 (DC-CK1), alternative macrophage activation-associated CC chemokine-1 (AMAC-1), and macrophage inflammatory protein-4 (MIP-4).

^ ^a ^b ^c ENSG00000278167, ENSG00000278006 GRCh38: Ensembl release 89: ENSG00000275385, ENSG00000278167, ENSG00000278006 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] ENSG00000278167, ENSG00000278006 GRCh38: Ensembl release 89: ENSG00000275385, ENSG00000278167, ENSG00000278006 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

CCL18 information

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CCL18

PARC

Spironolactone

DDT

Steroid

Nicotinamide

Haematopoiesis

Quercetin

Testosterone

Tumor necrosis factor

Cytokine

Metandienone

Bisphenol A

Interferon

Enclomifene

Boldenone undecylenate

Dehydroepiandrosterone

Estrogen

Androstenedione

Aldosterone

Estradiol

Triclosan

Tamoxifen

Endocrine disruptor

Chemokine

Ubiquitin

Transfer factor