positive regulation of vascular endothelial growth factor production
G protein-coupled receptor signaling pathway
regulation of complement activation
phospholipase C-activating G protein-coupled receptor signaling pathway
neutrophil degranulation
leukocyte migration
cell chemotaxis
complement receptor mediated signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
719
12267
Ensembl
ENSG00000171860
ENSMUSG00000040552
UniProt
Q16581
O09047
RefSeq (mRNA)
NM_004054 NM_001326475 NM_001326477
NM_009779
RefSeq (protein)
NP_001313404 NP_001313406 NP_004045
NP_033909
Location (UCSC)
Chr 12: 8.06 – 8.07 Mb
Chr 6: 122.82 – 122.83 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system.[5][6]
The receptor binds to complement component C3a, although there is limited evidence that this receptor also binds C4a in lesser mammals. This has yet to be proven true in humans.[7] C3a receptor modulates immunity,[8] arthritis, diet-induced obesity[9] and cancers.[10]
^ abcGRCh38: Ensembl release 89: ENSG00000171860 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000040552 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD (February 1996). "cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1305 (1–2): 39–43. doi:10.1016/0167-4781(95)00209-x. PMID 8605247.
^Klos A, Wende E, Wareham KJ, Monk PN (January 2013). "International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10.1124/pr.111.005223. PMID 23383423.
^Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS (October 2013). "Immune cell-derived C3a and C5a costimulate human T cell alloimmunity". American Journal of Transplantation. 13 (10): 2530–9. doi:10.1111/ajt.12405. PMC 3809075. PMID 24033923.
^Lim J, Iyer A, Suen JY, Seow V, Reid RC, Brown L, Fairlie DP (February 2013). "C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling". FASEB Journal. 27 (2): 822–31. doi:10.1096/fj.12-220582. PMID 23118029. S2CID 25562647.
^Sayegh ET, Bloch O, Parsa AT (August 2014). "Complement anaphylatoxins as immune regulators in cancer". Cancer Medicine. 3 (4): 747–58. doi:10.1002/cam4.241. PMC 4303144. PMID 24711204.
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