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Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific...
CA, et al. (2014). "Association Between Busulfan Exposure and Outcome in Children Receiving Intravenous Busulfan Before Hematopoietic Stem Cell Transplantation"...
the result is called limpet attachment of the drug molecule to the DNA. Busulfan is an example of a dialkylating agent: it is the methanesulfonate diester...
agents, some of them are used as alkylating antineoplastic agents in the treatment of cancer, e.g. Busulfan. Römpp CD 2006, Georg Thieme Verlag 2006 v t e...
also used as an excipient in drugs, e.g. in Vumon (teniposide), Busulfex (busulfan) or Amsidine (amsacrine). Dimethylacetamide, like most simple alkyl amides...
ketorolac, metamizole, pentazocine Some cancer treatments like bexarotene, busulfan, chlorambucil, estramustine, etoposide, flutamide, idarubicin, ifosfamide...
administered orally (e.g. specialty drugs, melphalan (trade name Alkeran), busulfan, capecitabine). University of Pittsburgh Medical Center National Cancer...
chemotherapy (especially alkylating agents such as melphalan, cyclophosphamide, busulfan, and chlorambucil) or radiation (therapeutic or accidental), or both (e...
interfere with DNA replication and transcription by modifying DNA bases. Busulfan, Carmustine, Mechlorethamine Intercalating agents interfere with DNA replication...
COVID-19 Certain medications, e.g. amiodarone, bleomycin (pingyangmycin), busulfan, apomorphine, and nitrofurantoin. Radiation therapy to the chest Pulmonary...
Brian P. (18 April 2019). "Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1". New England Journal of Medicine. 380 (16): 1525–1534...
2019. Two main studies showed that treosulfan is at least as effective as busulfan, another medicine used to prepare patients for haematopoietic stem cell...
et al. (April 2019). "Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1". The New England Journal of Medicine. 380 (16):...
Brazil, and South Africa. In a British study, it was found that Aspen's Busulfan, a cancer treatment used by the British National Health Service, had undergone...
Masatoshi; Takagi, Michiaki; Oberg, Kerby C.; Ogino, Toshihiko (2007). "Busulfan-induced central polydactyly, syndactyly and cleft hand or foot: A common...
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