Mucin 5B information

MUC5B
Identifiers
Aliases	MUC5B, MG1, MUC-5B, MUC5, MUC9, mucin 5B, oligomeric mucus/gel-forming
External IDs	OMIM: 600770; MGI: 1921430; HomoloGene: 136756; GeneCards: MUC5B; OMA:MUC5B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,262,172 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,426,821 bp
RNA expression pattern
	Top expressed in
	trachea; ; gallbladder; ; bronchus; ; bronchial epithelial cell; ; minor salivary glands; ; rectum; ; pancreatic ductal cell; ; canal of the cervix; ; oral cavity; ; urethra;
	Top expressed in
	trachea; ; olfactory epithelium; ; right lung; ; cervix; ; right lung lobe; ; conjunctival fornix; ; cochlea; ; carotid body; ; left lung; ; aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi lumen; extracellular region; extracellular exosome; intracellular membrane-bounded organelle; plasma membrane; extracellular space;
Biological process	O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	727897
	74180
	ENSG00000117983
	ENSMUSG00000066108
	Q9HC84
	n/a
	NM_002458
	NM_028801
	NP_002449
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene ^[5]^[6]^[7]^[8] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117983 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066108 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Desseyn JL, Buisine MP, Porchet N, Aubert JP, Laine A (November 1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon". The Journal of Biological Chemistry. 273 (46): 30157–64. doi:10.1074/jbc.273.46.30157. PMID 9804771.
^ Desseyn JL, Guyonnet-Dupérat V, Porchet N, Aubert JP, Laine A (November 1997). "Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family". The Journal of Biological Chemistry. 272 (4): 3168–78. doi:10.1074/jbc.272.6.3168. PMID 9013550.
^ Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A (1997). "Genomic organization of the 3' region of the human mucin gene MUC5B". The Journal of Biological Chemistry. 272 (27): 16873–83. doi:10.1074/jbc.272.27.16873. PMID 9201995.
^ "Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming".
^ "MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-06-10.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117983 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066108 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9804771-5] Desseyn JL, Buisine MP, Porchet N, Aubert JP, Laine A (November 1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon". The Journal of Biological Chemistry. 273 (46): 30157–64. doi:10.1074/jbc.273.46.30157. PMID 9804771.

[pmid9013550-6] Desseyn JL, Guyonnet-Dupérat V, Porchet N, Aubert JP, Laine A (November 1997). "Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family". The Journal of Biological Chemistry. 272 (4): 3168–78. doi:10.1074/jbc.272.6.3168. PMID 9013550.

[pmid9201995-7] Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A (1997). "Genomic organization of the 3' region of the human mucin gene MUC5B". The Journal of Biological Chemistry. 272 (27): 16873–83. doi:10.1074/jbc.272.27.16873. PMID 9201995.

[entrez-8] "Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming".

[9] "MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-06-10.

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