Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Benzylfentanyl (R-4129) is a fentanyl analog.[1] It was temporarily placed in the US Schedule I by emergency scheduling in 1985 due to concerns about its potential for abuse as a designer drug, but this placement was allowed to expire and benzylfentanyl was formally removed from controlled substance listing in 2010, after the DEA's testing determined it to be "essentially inactive" as an opioid.[2] Benzylfentanyl has a Ki of 213 nM at the mu opioid receptor, binding around 1/200 as strong as fentanyl itself,[3] though it is still slightly more potent than codeine.[4]
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea, and potentially serious respiratory depression which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[5]
^Ruangyuttikarn, W; Law, MY; Rollins, DE; Moody, DE (1990). "Detection of fentanyl and its analogs by enzyme-linked immunosorbent assay". Journal of Analytical Toxicology. 14 (3): 160–4. doi:10.1093/jat/14.3.160. PMID 2374405.
^Correction of Code of Federal Regulations: Removal of Temporary Listing of Benzylfentanyl and Thenylfentanyl as Controlled Substances
^Utilization of a radioreceptor assay for the analysis of fentanyl analogs in urine Mario Enrique Alburges
^Chen ZR, Irvine RJ, Somogyi AA, Bochner F (1991). "Mu receptor binding of some commonly used opioids and their metabolites". Life Sci. 48 (22): 2165–71. doi:10.1016/0024-3205(91)90150-a. PMID 1851921.
^Jane Mounteney; Isabelle Giraudon; Gleb Denissov; Paul Griffiths (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". The International Journal of Drug Policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.
Benzylfentanyl (R-4129) is a fentanyl analog. It was temporarily placed in the US Schedule I by emergency scheduling in 1985 due to concerns about its...
molecular formula C22H28N2O may refer to: Fentanyl Isofentanyl, or 3-methyl-benzylfentanyl α-Methylacetylfentanyl 4-Methylphenethylacetylfentanyl This set index...
by Paul Janssen involves synthesis of benzylfentanyl from N-Benzyl-4-Piperidone. The resulting benzylfentanyl is used as feedstock to norfentanyl. It...
Isofentanyl (3-methyl-benzylfentanyl) is an opioid analgesic that is an analog (and structural isomer) of fentanyl first invented in 1973, and which has...
pyrrolidine derivative, as well as other related compounds such as benzylfentanyl and ethoheptazine. The β-hydroxy derivative is slightly more potent...
fentanyl itself but still 5–6× the potency of morphine in animal tests. Benzylfentanyl Homofentanyl Diampromide Fentanyl azepane Isofentanyl Phenampromide...
in Belgium. It is related in chemical structure to compounds such as benzylfentanyl and bezitramide, though it is sufficiently structurally distinct to...
methylene, which shortens the chain by one carbon length, creates the benzylfentanyl structure. The addition of a methylene, which lengthens the chain by...
acid diethylamide N-(1-benzylpiperidin-4-yl)-N-phenylpropionamide (benzylfentanyl) and its salts fentanyl N-phenylpiperidin-4-amine(4-anilinopiperidine;...
322.452 g/mol, exact mass: 322.2045 u) may refer to: Acetylfentanyl Benzylfentanyl (R-4129) This set index page lists chemical structure articles associated...
believed to be less potent than butyrfentanyl but more potent than benzylfentanyl. In one study, it fully substituted for oxycodone and produced antinociception...
4-Fluorobutyrfentanyl 4-Fluorofentanyl α-Methylfentanyl Acetylfentanyl Benzylfentanyl Furanylfentanyl Homofentanyl List of fentanyl analogues Strayer KE (2018)...
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