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Norfentanyl information


Norfentanyl
Legal status
Legal status
  • BR: Class D1 (Drug precursors)[1]
Identifiers
IUPAC name
  • N-phenyl-N-piperidin-4-ylpropanamide
CAS Number
  • 1609-66-1
PubChem CID
  • 259381
ChemSpider
  • 227671 ☒N
UNII
  • 2MK6D8JV6J
ChEBI
  • CHEBI:62685
ChEMBL
  • ChEMBL3560524
CompTox Dashboard (EPA)
  • DTXSID2057657 Edit this at Wikidata
ECHA InfoCard100.015.040 Edit this at Wikidata
Chemical and physical data
FormulaC14H20N2O
Molar mass232.327 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CCC(=O)N(C1CCNCC1)C2=CC=CC=C2
InChI
  • InChI=1S/C14H20N2O/c1-2-14(17)16(12-6-4-3-5-7-12)13-8-10-15-11-9-13/h3-7,13,15H,2,8-11H2,1H3
  • Key:PMCBDBWCQQBSRJ-UHFFFAOYSA-N

Norfentanyl is an inactive synthetic opioid analgesic drug precursor.[2] It is an analog and metabolite of fentanyl with the removal of the phenethyl moiety (or functional group) from fentanyl chemical structure.[3][4][5][6][7][8][9][10]

  1. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 15 August 2023.
  2. ^ "Fentanyl". Elsevier.
  3. ^ Sofalvi, Szabolcs (2017). "An LC–MS-MS method for the analysis of carfentanil, 3-methylfentanyl, 2-furanyl fentanyl, acetyl fentanyl, fentanyl and norfentanyl in postmortem and impaired-driving cases". Journal of Analytical Toxicology. 41 (6): 473–483. doi:10.1093/jat/bkx052. PMID 28830122.
  4. ^ Bista, Sudeep R. (2014). "Development, validation and application of an HPLC–MS/MS method for the determination of fentanyl and nor-fentanyl in human plasma and saliva". Journal of Chromatography. B (960): 27-33.
  5. ^ Huynh, N-H.; et al. (2005). "Determination of fentanyl in human plasma and fentanyl and norfentanyl in human urine using LC–MS/MS". Journal of Pharmaceutical and Biomedical Analysis. 37 (5): 1095–1100. doi:10.1016/j.jpba.2004.09.024. PMID 15862690.
  6. ^ Poklis, Alphonse (2004). "Urine concentrations of fentanyl and norfentanyl during application of Duragesic® transdermal patches". Journal of Analytical Toxicology. 28 (6): 422–425. doi:10.1093/jat/28.6.422. PMID 15516290.
  7. ^ Coopman, Vera (2007). "LC–MS/MS analysis of fentanyl and norfentanyl in a fatality due to application of multiple Durogesic® transdermal therapeutic systems". Forensic Science International. 169 (2–3): 223–227. doi:10.1016/j.forsciint.2006.03.018. PMID 16650707.
  8. ^ Peer, Cody J. (2007). "Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases". Journal of Analytical Toxicology. 31 (8): 515–521. doi:10.1093/jat/31.8.515. PMID 17988466.
  9. ^ Vandergrift, Gregory W. (2018). "Paper spray mass spectrometry for the direct, semi-quantitative measurement of fentanyl and norfentanyl in complex matrices". Clinical Biochemistry. 54: 106–111. doi:10.1016/j.clinbiochem.2018.02.005. PMID 29432758.
  10. ^ Patton, Amy L. (2014). "Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS". Analytical Chemistry. 86 (3): 1760–1766. doi:10.1021/ac4036197. PMID 24354295.

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