Benign infantile epilepsy (BIE), also known as benign infantile seizures (BIS), is an epilepsy syndrome of which several forms have been described. The International League Against Epilepsy (ILAE) classify two main forms of the syndrome (familial and nonfamilial)[1] though several other forms have been described in the academic literature. Affected children, who have no other health or developmental problems, develop seizures during infancy. These seizures have focal origin within the brain but may then spread to become generalized seizures. The seizures may occur several times a day, often grouped in clusters over one to three days followed by a gap of one to three months.[2] Treatment with anticonvulsant drugs is not necessary but they are often prescribed and are effective at controlling the seizures. Sodium channel blockers in particular have been shown to be effective for benign infantile epilepsy.[3] This form of epilepsy resolves after one or two years, and appears to be completely benign. The EEG of these children, between seizures, is normal. The brain appears normal on MRI scan.[4][5]
The familial and nonfamilial forms have overlapping features and the presence of a family history of infantile seizures may be the only distinguishing criterion. The nonfamiliar form has a larger range of the onset of seizures: from three to twenty months with most occurring between five and six months. There is no difference between the sexes. With benign familial infantile epilepsy, the seizures onset from four to eight months of age.[4]
Some cases of nonfamilial benign infantile seizures occur during a case of mild gastroenteritis. Called benign infantile seizures associated with mild gastroenteritis (BIS with MG), the seizures only occur during this illness and do not recur. Infection with rotavirus is the most common cause.[4]
Although children with benign infantile epilepsy typically have a normal EEG between seizures, some infants have been found to have a characteristic abnormal EEG during sleep. Called benign infantile focal epilepsy with midline spikes and waves during sleep, these infants have few seizures and there may often be a family history.[4]
^Cite error: The named reference ilae2010 was invoked but never defined (see the help page).
^Treadwell, Jonathan (2024-02-16). "Systematic Review: Management of Infantile Epilepsies" (PDF). pcori.org.
Benigninfantileepilepsy (BIE), also known as benigninfantile seizures (BIS), is an epilepsy syndrome of which several forms have been described. The...
Benign familial infantileepilepsy (BFIE) is an epilepsy syndrome. Affected children, who have no other health or developmental problems, develop seizures...
PMID 35833911. Treadwell JR, Wu M, Tsou AY (2022). Management of InfantileEpilepsies: A Systematic Review (Report). doi:10.23970/AHRQEPCCER252. PMID 36383706...
epilepsy and genetic syndromes where it has shown particular usefulness. These include Dravet syndrome, infantile spasms, myoclonic-astatic epilepsy,...
Other names for it are "generalized flexion epilepsy", "infantile epileptic encephalopathy", "infantile myoclonic encephalopathy", "jackknife convulsions"...
neonatal epilepsy, PRRT2 or less commonly SCN2A or SCN8A in self-limited infantileepilepsy and SCN2A or KCNQ2 in self-limited neonatal-infantileepilepsy. These...
of inheritance. It is characterized by the association of benign familial infantileepilepsy (BIFE) at age 3–12 months and later in life with paroxysmal...
brain. There are two main types of tumors: malignant (cancerous) tumors and benign (non-cancerous) tumors. These can be further classified as primary tumors...
movements of the body. The child remains conscious during episodes of infantile masturbation and can be distracted from the behavior, which could help...
convulsions have no relation with epilepsy, and are caused by non-epileptic seizures. Convulsions can be caused by epilepsy, infections (including a severe...
tumours are discovered during routine ultrasound. In infancy, epilepsy, particularly infantile spasms, or developmental delay may lead to neurological tests...
symptoms and EEG may appear like Generalized epilepsy, Juvenile myoclonic epilepsy, benign childhood myoclonic epilepsy, and Huntington's disease. It is crucial...
generally included in the following categories: perinatal, infantile, childhood, adult, benign prenatal and odontohypophosphatasia. Although several clinical...
drug treatment given for infantile spasms and other types of epilepsy is also given to girls with Aicardi syndrome. Epilepsy is often difficult to treat...
with infantile convulsions and choreoathetosis (ICCA) syndrome, in which patients have afebrile seizures during infancy (benign familial infantile epilepsy)...
PMID 11245985. Malacarne M, Gennaro E, Madia F, et al. (2001). "Benign Familial Infantile Convulsions: Mapping of a Novel Locus on Chromosome 2q24 and Evidence...
spectrum disorder such as attention-deficit hyperactivity disorder and epilepsy. In medicine and in psychiatry, comorbidity is the presence of one or more...
Salt and pepper developmental regression syndrome, also known as Amish infantile epileptic syndrome or GM3 deficiency syndrome, is a rare autosomal recessive...
Seizures and epilepsy Focal Generalised Status epilepticus For more detailed coverage, see Template:Epilepsy Headache Migraine Cluster Tension For more...
Although the occurrence of epilepsy is higher in children with childhood disintegrative disorder, experts don't know whether epilepsy plays a role in causing...
Lennox-Gastaut syndrome, and in 1981 and 1982 the late variant of the benign childhood epilepsy with occipital paroxysms. After the Second World War he was influential...
Global Information