Sodium channel protein type 2 subunit alpha, is a protein that in humans is encoded by the SCN2A gene.[5] Functional sodium channels contain an ion conductive alpha subunit and one or more regulatory beta subunits. Sodium channels which contain sodium channel protein type 2 subunit alpha are sometimes called Nav1.2 channels.
^ abcGRCh38: Ensembl release 89: ENSG00000136531 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000075318 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cite error: The named reference entrez was invoked but never defined (see the help page).
protein type 2 subunit alpha, is a protein that in humans is encoded by the SCN2A gene. Functional sodium channels contain an ion conductive alpha subunit...
hyperexcitability. The final type of GEFS+ is caused by mutations in the SCN2A gene, which encodes a sodium channel α subunit. The first associated mutation...
gene does not necessarily mean that the patient has Dravet syndrome. - SCN2A: This gene encodes the alpha-2 subunit of the sodium ion channel (Nav1.2)...
have been identified with LQT8. The sodium ion channel genes SCN1A, SCN1B, SCN2A, and SCN8A and the potassium channel KCNA1 have been implicated in both...
causative genes for GEFS+ are the sodium channel α subunit genes SCN1A and SCN2A and the β subunit gene SCN1B. Mutations in the GABAA receptor γ subunit...
Nishizaki K, Meyer NC, Smith RJ (February 2001). "Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus". Gene. 264...
Bender, Kevin J. (2018-07-01). "Progress in Understanding and Treating SCN2A-Mediated Disorders". Trends in Neurosciences. 41 (7): 442–456. doi:10.1016/j...
self-limited neonatal epilepsy, PRRT2 or less commonly SCN2A or SCN8A in self-limited infantile epilepsy and SCN2A or KCNQ2 in self-limited neonatal-infantile epilepsy...
seizures (BFNIS) has been described, which is due to a mutation in the SCN2A gene. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, et al. Revised...
; Buxbaum, J. D.; Meisler, M. H. (2003-02-01). "Sodium channels SCN1A, SCN2A and SCN3A in familial autism". Molecular Psychiatry. 8 (2): 186–194. doi:10...
the alpha subunit of the mammalian voltage-gated sodium channel Nav1.2 (SCN2A). Binding of Magi 5 to the sodium channels shifts both activation and inactivation...
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