Bendamustine, sold under the brand name Treanda among others, is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma.[3][4] It is given by injection into a vein.[3]
Common side effects include low blood cell counts, fever, nausea, diarrhea, loss of appetite, cough, and rash.[3] Other severe side effects include allergic reactions and increased risk of infection.[3] Use in pregnancy is known to harm the baby.[3] Bendamustine is in the alkylating agents family of medication.[3] It works by interfering with the function of DNA and RNA.[3]
Bendamustine was approved for medical use in the United States in 2008.[3] It is on the World Health Organization's List of Essential Medicines.[5][6] It was originally made from nitrogen mustard.[3]
^"Prescription medicines: registration of new chemical entities in Australia, 2014". Therapeutic Goods Administration (TGA). 21 June 2022. Archived from the original on 10 April 2023. Retrieved 10 April 2023.
^Dubbelman AC, Rosing H, Darwish M, D'Andrea D, Bond M, Hellriegel E, et al. (March 2013). "Pharmacokinetics and excretion of 14C-bendamustine in patients with relapsed or refractory malignancy". Drugs in R&D. 13 (1): 17–28. doi:10.1007/s40268-012-0001-5. PMC 3627029. PMID 23322528.
^ abcdefghi"Bendamustine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 579. ISBN 9780857111562.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Bendamustine, sold under the brand name Treanda among others, is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia (CLL)...
include cyclophosphamide, chlorambucil, uramustine, melphalan, and bendamustine. Bendamustine has recently re-emerged as a viable chemotherapeutic treatment...
November 2020. Polatuzumab vedotin is indicated in combination with bendamustine and a rituximab product for the treatment of adults with relapsed or...
pharmaceutical agents which contain a benzimidazole group include abemaciclib, bendamustine, dabigatran, daridorexant, and glasdegib. In printed circuit board manufacturing...
multicenter, open-label trial of venetoclax with rituximab (VEN+R) versus bendamustine with rituximab (B+R) in 389 participants with CLL who had received at...
progression-free survival (PFS) than CHOP regimens. A less intensive option is bendamustine with rituximab. Second line treatment may include fludarabine, combined...
including: 1) rituximab combined with the chemotherapeutic alkylating agent bendamustine; 2) rituximab combined with the chemotherapeutic agent fludarabine and...
Lukas J, Zielinski CC, Müllauer L, Raderer M (2014). "Rituximab plus bendamustine is active in pretreated patients with extragastric marginal zone B cell...
RXDX-107) a nanoformulation of a modified bendamustine with potential activity in solid tumours. Bendamustine Rapid Infusion as therapy for CLL and NHL...
patients affected by relapsed/refractory multiple myeloma treated with bendamustine-bortezomib-dexamethasone". Supportive Care in Cancer. 24 (12): 4835–4837...
combination (e.g. chlorambucil + rituximab or fludarabine + rituximab or bendamustine + rituximab) immunotherapy plus chemotherapy regimen. In general, overall...
for chronic lymphocytic leukemia. It is also used in combination with bendamustine followed by obinutuzumab monotherapy for the treatment of people with...
Treatment of diffuse large B-cell lymphoma when used in combination with bendamustine and rituximab. Led by Chief Diversity Officer, Quita Beeler Highsmith...
offering the product licensed in the US and EU markets.[citation needed] Bendamustine Lomustine Semustine CID 2578 from PubChem "Carmustine 100mg Powder and...
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