Microscopic appearance of cells stained with a basic dye
Main staining types when using hematoxylin and eosin (H&E).A Basophil granulocyte stains dark purple upon H&E staining.
Basophilic is a technical term used by pathologists. It describes the appearance of cells, tissues and cellular structures as seen through the microscope after a histological section has been stained with a basic dye. The most common such dye is haematoxylin.
The name basophilic refers to the characteristic of these structures to be stained very well by basic dyes. This can be explained by their charges. Basic dyes are cationic, i.e. contain positive charges, and thus they stain anionic structures (i.e. structures containing negative charges), such as the phosphate backbone of DNA in the cell nucleus and ribosomes.[1]
"Basophils" are cells that "love" (from greek "-phil") basic dyes, for example haematoxylin, azure and methylene blue. Specifically, this term refers to:
basophil granulocytes
anterior pituitary basophils
An abnormal increase in basophil granulocytes is therefore also described as basophilia.[2]
The opposite of basophilic structures are acidophilic structures, also called eosinophilic. These structures contain many positive charges and are thus strongly stained by anionic dyes like eosin. A typical combination of basophilic and eosinophilic dyes is the H&E stain, which visualizes basophilic structures in blue and eosinophilic structures in red.[1]
^ abLüllmann-Rauch, Renate (2019). Taschenlehrbuch Histologie [Textbook histology] (in German). Georg Thieme Verlag. ISBN 978-3-13-242529-3.
Basophilic stippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes...
Basophilic is a technical term used by pathologists. It describes the appearance of cells, tissues and cellular structures as seen through the microscope...
diseases). When stained with the usual dyes, the cytoplasm is distinctly basophilic and relatively more abundant than in myeloblasts or promyelocytes, even...
FTD are neuronal intermediate filament inclusion disease (NIFID) and basophilic inclusion body disease (BIBD). Other related disorders include corticobasal...
Headings (MeSH) Pronormoblasts Presented by the University of Virginia Basophilic Normoblasts Presented by the University of Virginia Polychromatophilic...
pronormoblast (also commonly called an proerythroblast or a rubriblast), then a basophilic or early normoblast (also commonly called an erythroblast), then a polychromatophilic...
resemble normal cells and produce the cartilaginous matrix (amorphous, basophilic material). Characteristic features of this tumor include the vascular...
Acute basophilic leukemia is a rare form of acute myeloid leukemia where blasts are accompanied by abnormal basophils in all stages of differentiation...
Pappenheimer bodies are abnormal basophilic granules of iron found inside red blood cells on routine blood stain. They are a type of inclusion body composed...
hematoxylin and eosin (H&E) histological or cytological preparations. Whereas basophilic white blood cells stain dark blue and eosinophilic white blood cells stain...
of their hormone production. Historically they were classed as either basophilic, acidophilic, or chromophobic on the basis of whether or not they took...
Features Diameter Nuclei Notes basal cell round to cylindrical, narrow basophilic cytoplasmic space 12-14 μm distinct, 8–10 μm in size only in case of severe...
granulopoiesis. B., N. and E. stand for Basophilic, Neutrophilic and Eosinophilic, respectively – as in Basophilic promyelocyte. For lymphocytes, the T and...
the nucleus and loss of Nissl bodies which are normally stained blue (basophilic) on hematoxylin & eosin staining (H&E stain). This leaves only the degraded...
some non-neuronal cells, where they are referred to as ergastoplasm, basophilic bodies, or chromophilic substance. While these organelles differ in some...
have cells with prominent perinuclear vacuolization around pyknotic, basophilic, centrally located nuclei that may be located in the granular layer. These...
production of red blood cells by targeting CFU-E, proerythroblast and basophilic erythroblast subsets in the differentiation. Erythropoietin has its primary...
iron-laden mitochondria form a ring around the nucleus. It is a subtype of basophilic granules of the erythrocyte, but which can only be seen in bone marrow...
affect one or more cell lines and can be neutrophilic, eosinophilic, basophilic, monocytosis, or lymphocytosis. Neutrophilia is an increase in the absolute...
(or Nissl substance) are seen when nerve cell bodies are stained with a basophilic ("base-loving") dye. These structures consist of rough endoplasmic reticulum...
consist around 5% of the anterior pituitary lobe cells. Thyrotropes appear basophilic in histological preparations. Anterior pituitary Hormone List of human...
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by being B cell-derived lymphoid cells that have moderate-to-abundant basophilic cytoplasm and a prominent, centrally located, trapezoid-shaped single...
(e.g. SLE) Some forms of vasculitis Cholesterol embolism (transiently) Basophilic leukocytosis Basophilia (rare) Myeloproliferative disease, e.g. Chronic...
A castration cell is a basophilic cell with a large vacuole found in the anterior pituitary after castration, effective (drug) castration, or long-term...
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