Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Baccatin III is an isolate from the yew tree (Genera Taxus). Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol).
In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synthesizing baccatin III (10-deacetylbaccatin III 10-O-acetyltransferase), to the mushroom Flammulina velutipes.[1] Researchers achieved the same accomplishment with Escherichia coli in 2000.[2]
^Han F, Kang LZ, Zeng XL, Ye ZW, Guo LQ, Lin JF (2014). "Bioproduction of baccatin III, an advanced precursor of paclitaxol with transgenic Flammulina velutipes expressing 10-Deacetylbaccatin III-10-O-acetyl transferase gene". J Sci Food Agric. 94 (12): 2376–2383. doi:10.1002/jsfa.6562. PMID 24403190.
^Walker K, Croteau R (2000). "Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli". Proc Natl Acad Sci U S A. 97 (2): 583–7. Bibcode:2000PNAS...97..583W. doi:10.1073/pnas.97.2.583. PMC 15373. PMID 10639122.
BaccatinIII is an isolate from the yew tree (Genera Taxus). BaccatinIII is a precursor to the anti-cancer drug paclitaxel (Taxol). In 2014, researchers...
name Taxotere. Taxanes, including paclitaxel, 10-deacetylbaccatin III, baccatinIII, paclitaxel C, and 7-epipaclitaxel, have been found in the leaves...
hydroxylation reactions, and a few others, are needed to convert taxadiene to baccatinIII. Enzymatically, taxadiene is produced from geranylgeranyl pyrophosphate...
(the final product is baccatinIII which lacks the amide tail found in taxol itself) and that it is racemic (the product baccatinIII is optically inactive)...
Richard C. A.; Bornmann, William G. (1996-01-01). "Total Synthesis of BaccatinIII and Taxol". Journal of the American Chemical Society. 118 (12): 2843–2859...
potential. The paclitaxel molecule consists of a tetracyclic core called baccatinIII and an amide tail. The core rings are conveniently called (from left...
the formulation of docetaxel – an esterified product of 10-deacetyl baccatinIII, which is extracted from the renewable and more readily available leaves...
Coburn, Craig A.; Di Grandi, Martin J. (1996-01-01). "Total Synthesis of BaccatinIII and Taxol". Journal of the American Chemical Society. 118 (12): 2843–2859...
luteus can be used for enzymatic hydrolysis for producing 10-Deacetyl BaccatinIII. Prauser, H. (24 January 2007). "Nocardioides luteus spec. nov". Zeitschrift...
triethylsilyl ether of the naturally occurring compound baccatinIII. The related compound, 10-deacetylbaccatin III, is found in Taxus baccata, also known as the...
cell lines: Initiation, selection and characterization in terms of growth, and of baccatinIII and paclitaxel production. Biocell, 34 (1), 1-6. v t e...
doi:10.1021/ja01084a034. Danishefsky; et al. (1996). "Total Synthesis of BaccatinIII and Taxol". Journal of the American Chemical Society. 118 (12): 2843–2859...
hydroxy carbonate 50, both TES groups were removed (HF, pyr) to triol 51 (baccatinIII) and the C7 hydroxyl group was back-protected to 52. The amide tail synthesis...
resulted from the tail addition of the Ojima lactam to alcohol 51, which is baccatinIII (the original target molecule of the Danishefsky synthesis). Alcohol...
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