The Takahashi Taxol total synthesis published by Takashi Takahashi in 2006 is one of several methods in taxol total synthesis.[1] The method starts from geraniol and differs from the other 6 published methods that it is a formal synthesis (the final product is baccatin III which lacks the amide tail found in taxol itself) and that it is racemic (the product baccatin III is optically inactive). A key feature of the published procedure is that several synthetic steps (construction of rings A, B and C) were performed in an automated synthesizer on a scale up to 300 gram and that purification steps were also automated.
^A Formal Total Synthesis of Taxol Aided by an Automated Synthesizer Takayuki Doi, Shinichiro Fuse, Shigeru Miyamoto, Kazuoki Nakai, Daisuke Sasuga and Takashi Takahashi Chemistry an Asian J.; (Article); 2006; 1(3); 370-383. DOI Abstract
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