BACH2 information

BACH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OHU, 3OHV
Identifiers
Aliases	BACH2, BTBD25, BTB domain and CNC homolog 2, IMD60
External IDs	OMIM: 605394; MGI: 894679; HomoloGene: 7240; GeneCards: BACH2; OMA:BACH2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	90,296,843 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	32,586,108 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; epithelium of nasopharynx; ; oocyte; ; bone marrow; ; secondary oocyte; ; thymus; ; ganglionic eminence; ; tonsil; ; lymph node; ; ventricular zone;
	Top expressed in
	zygote; ; mesenteric lymph nodes; ; trigeminal ganglion; ; Rostral migratory stream; ; blood; ; tibiofemoral joint; ; spleen; ; hand; ; hair follicle; ; ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; ubiquitin-protein transferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; Cul3-RING ubiquitin ligase complex; nucleus; cytosol;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; protein ubiquitination; import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	60468
	12014
	ENSG00000112182
	ENSMUSG00000040270
	Q9BYV9
	P97303
	NM_001170794; NM_021813
	NM_001109661; NM_007521
	NP_001164265; NP_068585
	NP_001103131
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene.^[5]^[6]^[7] It contains a BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer ^[8] and a bZip_Maf domain at the C-terminus.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112182 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040270 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (August 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene. 19 (33): 3739–49. doi:10.1038/sj.onc.1203716. PMID 10949928.
^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (November 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood. 102 (9): 3317–22. doi:10.1182/blood-2002-12-3656. PMID 12829606.
^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2".
^ Rosbrook GO, Stead MA, Carr SB, Wright SC (January 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond" (PDF). Acta Crystallographica Section D. 68 (Pt 1): 26–34. Bibcode:2012AcCrD..68...26R. doi:10.1107/S0907444911048335. PMID 22194330.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112182 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040270 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10949928-5] Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (August 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene. 19 (33): 3739–49. doi:10.1038/sj.onc.1203716. PMID 10949928.

[pmid12829606-6] Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (November 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs". Blood. 102 (9): 3317–22. doi:10.1182/blood-2002-12-3656. PMID 12829606.

[entrez-7] "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2".

[8] Rosbrook GO, Stead MA, Carr SB, Wright SC (January 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond" (PDF). Acta Crystallographica Section D. 68 (Pt 1): 26–34. Bibcode:2012AcCrD..68...26R. doi:10.1107/S0907444911048335. PMID 22194330.

BACH2 information

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BACH2

Small Maf

List of human transcription factors

BZIP domain

BRIP1

PATZ1

BACH1

FARS2

MAFG

MAFK