Asymmetric hydrogenation is a chemical reaction that adds two atoms of hydrogen to a target (substrate) molecule with three-dimensional spatial selectivity. Critically, this selectivity does not come from the target molecule itself, but from other reagents or catalysts present in the reaction. This allows spatial information (what chemists refer to as chirality) to transfer from one molecule to the target, forming the product as a single enantiomer. The chiral information is most commonly contained in a catalyst and, in this case, the information in a single molecule of catalyst may be transferred to many substrate molecules, amplifying the amount of chiral information present. Similar processes occur in nature, where a chiral molecule like an enzyme can catalyse the introduction of a chiral centre to give a product as a single enantiomer, such as amino acids, that a cell needs to function. By imitating this process, chemists can generate many novel synthetic molecules that interact with biological systems in specific ways, leading to new pharmaceutical agents and agrochemicals. The importance of asymmetric hydrogenation in both academia and industry contributed to two of its pioneers — William Standish Knowles and Ryōji Noyori — being collectively awarded one half of the 2001 Nobel Prize in Chemistry.[1]
^"The Nobel Prize in Chemistry 2001". 2001-10-10.
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Asymmetrichydrogenation is a chemical reaction that adds two atoms of hydrogen to a target (substrate) molecule with three-dimensional spatial selectivity...
need for high-pressure molecular H2 used in conventional hydrogenation. Transfer hydrogenation usually occurs at mild temperature and pressure conditions...
non-catalytic hydrogenation takes place only at very high temperatures. Hydrogenation reduces double and triple bonds in hydrocarbons. Hydrogenation has three...
catalysts are effective for only one type of asymmetric reaction. For example, Noyori asymmetrichydrogenation with BINAP/Ru requires a β-ketone, although...
resolution of allylic alcohols by asymmetrichydrogenation of the olefin. Utilizing the Ru[BINAP] complex, selective hydrogenation can give high ee's of the unsaturated...
products. One of the more classic applications of DKR is Noyori's asymmetrichydrogenation. The presence of an acidic center between two carbonyl groups allows...
for asymmetrichydrogenation. Iridium complexes incorporating phosphinooxazoline ligands have been shown to be effective for 'classic' hydrogenation using...
prize with Ryōji Noyori for their work in asymmetric synthesis, specifically for his work in hydrogenation reactions. The other half was awarded to K...
measure the neutron flux level. Other uses of rhodium include asymmetrichydrogenation used to form drug precursors and the processes for the production...
precursor for catalysts for asymmetric transfer hydrogenation. For example, (cymene)Ru(S,S-TsDPEN) catalyzes the hydrogenation of benzil into (R,R)-hydrobenzoin...
autonomously described the use of phosphoramidite ligands for asymmetrichydrogenation. High enantioselectivities were reached, rivaling those using the...
prepared by hydrogenation of the corresponding quinoline using heterogeneous catalysts. Tetrahydroquinolines are produced by hydrogenation of quinolines...
complexes are often active for asymmetrichydrogenation both by traditional hydrogenation. and transfer hydrogenation. This property is the basis of the...
was introduced in 1991 by M.J. Burk and first demonstrated in asymmetrichydrogenation of certain enamide esters to amino acid precursors: Other chiral...
carboxylate by hydrolysis using lithium hydroxide in aqueous ethanol. Asymmetrichydrogenation using a ruthenium catalyst and a chiral bisphosphine ligand sets...
awarded in 2001 to Ryōji Noyori for contributions to the field of asymmetrichydrogenation. Ruthenium-promoted cobalt catalysts are used in Fischer–Tropsch...
complexes, in Noyori asymmetrichydrogenation: One of the most obvious applications of catalysis is the hydrogenation (reaction with hydrogen gas) of fats using...
names: authors list (link) Schuck, 1987: p. 17 William S. Knowles. ASYMMETRICHYDROGENATIONS. Nobel Lecture, December 8, 2001 E. Fred Schubert (2003). "1"...
team invented a way to selectively synthesize enantiomers via asymmetrichydrogenation. This was the first method for the catalytic production of pure...
component of catalysts used for asymmetrichydrogenation: Diisopinocampheylborane is an organoborane that is useful for asymmetric synthesis of secondary alcohols...
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