Chiral phosphinooxazoline (PHOX) in its free and coordinated forms
Phosphinooxazolines (often abbreviated PHOX) are a class of chiral ligands used in asymmetric catalysis. Their complexes are particularly effective at generating single enatiomers in reactions involving highly symmetric transition states, such as allylic substitutions, which are typically difficult to perform stereoselectively. The ligands are bidentate and have been shown to be hemilabile[1]
with the softer P‑donor being more firmly bound than the harder N‑donor.
^Braunstein, Pierre; Naud, Fre´de´ric; Rettig, Steven J. (2001). "A new class of anionic phosphinooxazoline ligands in palladium and ruthenium complexes: catalytic properties for the transfer hydrogenation of acetophenone". New Journal of Chemistry. 25 (1): 32–39. doi:10.1039/b004786o. ISSN 1144-0546.
and 7 Related for: Phosphinooxazolines information
Phosphinooxazolines (often abbreviated PHOX) are a class of chiral ligands used in asymmetric catalysis. Their complexes are particularly effective at...
assistant based on high order logic PHOX2A, a protein PHOX2B, a protein Phosphinooxazolines, a class of chiral ligands commonly abbreviated as PHOX (S)-iPr-PHOX...
number of alternative structures, such as axially chiral compounds. Phosphinooxazolines (PHOX) Trisoxazolines (TRISOX) Evans, David A.; Miller, Scott J.;...
classes of oxazoline based ligand include: Bis-oxazolines (BOX) Phosphinooxazolines (PHOX) for example (S)-iPr-PHOX Notable specialist oxazoline ligands...
doi:10.1002/hlca.19910740123. Helmchen, G. N.; Pfaltz, A. (2000). "PhosphinooxazolinesA New Class of Versatile, Modular P,N-Ligands for Asymmetric Catalysis"...
ligands, making significant contributions to the known chemistry of phosphinooxazolines. His current research activities remain focused on ligand development...
including examples of chiral recognition. Bisoxazoline ligands (BOX) Phosphinooxazolines (PHOX) Trisoxazolinylborate Trispyrazolylborate Ward, Benjamin D...
Global Information