A phosphoramidite ligand is any phosphorus-based ligand with the general formula P(OR1)(OR2)(NRR'). Chiral versions of these ligands, particularly those derived from the BINOL scaffold, are widely used in enantioselective synthesis. The application of phosphoramidites as effective monodentate ligands for transition metal catalysis was first reported by Dutch chemist Ben Feringa. The introduction of phosphoramidite ligands challenged the notion that high flexibility in the metal–ligand complex is detrimental for high stereocontrol.
General Structure of Phosphoramidite Ligand
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A phosphoramiditeligand is any phosphorus-based ligand with the general formula P(OR1)(OR2)(NRR'). Chiral versions of these ligands, particularly those...
analogs. Certain phosphoramidites are also used as monodentate chiral ligands in asymmetric synthesis. A large group of such ligands is derived from the...
9%. A similar system using iridium(I) and a very closely related phosphoramiditeligand is effective for the asymmetric hydrogenation of pyrrolidine-type...
taxane skeleton, uses a copper-based catalyst supported by a chiral phosphoramiditeligand for a conjugate carbonyl addition reaction. The second reaction...
course of oligonucleotide synthesis by the phosphoramidite method using commercial biotin phosphoramidite. Upon the standard deprotection, the conjugates...
dominant solvent used in oligonucleotide synthesis from nucleoside phosphoramidites. Industrially, it is used as a solvent for the manufacture of pharmaceuticals...
external chiral ligand, reduces the enantioselectivity. As BINOL-containing phosphoramidites have the properties of an intrinsic chiral ligand and simultaneously...
solid-phase synthesis using phosphoramidite chemistry. Methods for chemically synthesized TNA monomers (phosphoramidites and nucleoside triphosphates)...
production of nucleotides. A purified nucleoside is protected to create a phosphoramidite, which can then be used to obtain analogues not found in nature and/or...
synthesized enzymatically and can only be obtained synthetically using the phosphoramidite strategy or, for PNA, other methods of peptide synthesis.[citation...
Oligonucleotides are chemically synthesized using building blocks, protected phosphoramidites of natural or chemically modified nucleosides or, to a lesser extent...
Jaumann EA, Scheffer U, Prisner TF, Göbel MW (2018). "A cytidine phosphoramidite with protected nitroxide spin label: synthesis of a full-length TAR...
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