Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor.[2] In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia (HIT). In 2002, it was approved for use during percutaneous coronary interventions in patients who have HIT or are at risk for developing it. In 2012, it was approved by the MHRA in the UK for anticoagulation in patients with heparin-induced thrombocytopenia Type II (HIT) who require parenteral antithrombotic therapy.[3]
Argatroban is given intravenously and drug plasma concentrations reach steady state in 1–3 hours.[4] Argatroban is metabolized in the liver and has a half-life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared).
^"Argatroban injection, solution". DailyMed. Retrieved 10 June 2021.
^"UK launch for Mitsubishi's blood thinner Exembol". 3 July 2012.
^Dhillon, S (2009). "Argatroban: A Review of its Use in the Management of Heparin-Induced Thrombocytopenia". Am J Cardiovasc Drugs. 9 (4): 261–82. doi:10.2165/1120090-000000000-00000. PMID 19655821.
Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration...
specialized injectable products in the US, Europe and MENA including argatroban, fentanyl, phenylephrine, robaxin, and iron gluconate. The company sells...
Treatment may include a direct thrombin inhibitor, such as lepirudin or argatroban. Other "blood thinners" sometimes used in this setting include bivalirudin...
residue from arginine itself (e.g. argatroban) or arginine-like substrates such as benzamidine (e.g. NAPAP). Argatroban is a small univalent DTI formed from...
autoimmune manner, in favor of alternative anticoagulant medications (such as argatroban or danaparoid). Heparin appears to be relatively safe for use during pregnancy...
Han Y, Custer J, et al. (2007). "A case series describing the use of argatroban in patients on extracorporeal circulation". ASAIO Journal. 53 (4): 460–463...
Eptifibatide Tirofiban Others: oprelvekin, romiplostim, eltrombopag, argatroban Platelet transfusion is most frequently used to correct unusually low...
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