In immunology, affinity maturation is the process by which TFH cell-activated B cells produce antibodies with increased affinity for antigen during the course of an immune response. With repeated exposures to the same antigen, a host will produce antibodies of successively greater affinities. A secondary response can elicit antibodies with several fold greater affinity than in a primary response. Affinity maturation primarily occurs on membrane immunoglobulin of germinal center B cells and as a direct result of somatic hypermutation (SHM) and selection by TFH cells.[1]
^Victora, Gabriel D.; Nussenzweig, Michel C. (2012-04-23). "Germinal Centers". Annual Review of Immunology. 30 (1): 429–457. doi:10.1146/annurev-immunol-020711-075032. ISSN 0732-0582. PMID 22224772. S2CID 20168324.
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In immunology, affinitymaturation is the process by which TFH cell-activated B cells produce antibodies with increased affinity for antigen during the...
recalled in a secondary immune response, undergoing class switching, affinitymaturation, and differentiating into antibody-secreting cells. Antibodies are...
and affinitymaturation directed by somatic hypermutation. These processes are facilitated by TFH cells within the GC and generate both high-affinity memory...
production, germinal center formation and isotype switching, and affinitymaturation and memory cell generation. It also refers to the effector functions...
increase or decrease the affinity of the surface receptor for a particular antigen, a progression called affinitymaturation. After acquiring these mutations...
confront it (e.g. microbes). A major component of the process of affinitymaturation, SHM diversifies B cell receptors used to recognize foreign elements...
undergo a process known as affinitymaturation. This process favors, by selection for the ability to bind antigen with higher affinity, the activation and growth...
activity can be highly specific is the antibody-antigen system. Affinitymaturation typically leads to highly specific interactions, whereas naive antibodies...
not have high affinity for antigen, mutations in the FR that create a more flexible structure may allow for higher affinitymaturation. Natural mutations...
and the affinity increased 1-5 million fold to low picomolar values through phage display affinitymaturation. To provide the soluble, affinity enhanced...
produce. This phenomenon underscores the process of affinitymaturation, whereby greater affinity antibodies are produced and selected for after antigen...
formation of germinal centers and therefore prohibiting antibody affinitymaturation, an important process in the adaptive immune system. In 1991, three...
MacKenzie, C.; Hall, J. Christopher (2007-07-01). "Isolation and affinitymaturation of hapten-specific antibodies". Biotechnology Advances. 25 (4): 333–352...
activation by antigens. Activation leads to clonal expansion, and affinitymaturation. Mature lymphocytes recirculate between the blood and the secondary...
entered the CSF and underwent affinitymaturation after facing GlialCAM, which led consequently to the production of high affinity anti-GlialCAM antibodies...
hence prevail. Conversely, antibodies also simultaneously evolve by affinitymaturation during the course of an immune response, thereby improving recognition...
system. A major step in affinitymaturation, somatic hypermutation helps B cells produce antibodies with greater antigen affinity. Somatic mutations accumulate...
temperatures or in harsh solvents Improving binding affinity of therapeutic antibodies (Affinitymaturation) and the activity of de novo designed enzymes Altering...
time called affinitymaturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody...
‘goldilocks zone’ for affinity will be available for subsequent T helper stimulation, allowing for class switching, affinitymaturation and thus, resulting...
disease. Wikimedia Commons has media related to Adaptive immunity. Affinitymaturation Allelic exclusion Anergy Immune response Immune tolerance Immunosuppression...
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