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Chemical specificity is the ability of binding site of a macromolecule (such as a protein) to bind specific ligands. The fewer ligands a protein can bind, the greater its specificity.
Specificity describes the strength of binding between a given protein and ligand. This relationship can be described by a dissociation constant, which characterizes the balance between bound and unbound states for the protein-ligand system.[1] In the context of a single enzyme and a pair of binding molecules, the two ligands can be compared as stronger or weaker ligands (for the enzyme) on the basis of their dissociation constants. (A lower value corresponds to a stronger binding.)
Specificity for a set of ligands is unrelated to the ability of an enzyme to catalyze a given reaction, with the ligand as a substrate.[1]
If a given enzyme has a high chemical specificity, this means that the set of ligands to which it binds is limited, such that neither binding events nor catalysis can occur at an appreciable rate with additional molecules.
An example of a protein-ligand pair whose binding activity can be highly specific is the antibody-antigen system.[2] Affinity maturation typically leads to highly specific interactions, whereas naive antibodies are promiscuous and bind a larger number of ligands.[3] Conversely, an example of a protein-ligand system that can bind substrates and catalyze multiple reactions effectively is the Cytochrome P450 system, which can be considered a promiscuous enzyme due to its broad specificity for multiple ligands. Proteases are a group of enzymes that show a broad range of cleavage specificities. Promiscuous proteases as digestive enzymes unspecifically degrade peptides, whereas highly specific proteases are involved in signaling cascades.[4]
^ abEaton, Bruce E.; Gold, Larry; Zichi, Dominic A. (1995-10-01). "Let's get specific: the relationship between specificity and affinity". Chemistry & Biology. 2 (10): 633–638. doi:10.1016/1074-5521(95)90023-3. PMID 9383468.
^Tanford, Charles (1968). "Chemical basis for antibody diversity and specificity". Accounts of Chemical Research. 1 (6): 161–167. doi:10.1021/ar50006a001.
^Fernández-Quintero, Monica L.; Georges, Guy; Varga, Janos M.; Liedl, Klaus R. (2021). "Ensembles in solution as a new paradigm for antibody structure prediction and design". mAbs. 13 (1): e1923122. doi:10.1080/19420862.2021.1923122. PMC 8158028. PMID 34030577.
^Cite error: The named reference Fuchs was invoked but never defined (see the help page).
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