Bilateral mydriasis given the observational diagnosis Adie's pupils by an ophthalmologist
Pronunciation
/ˈeɪdi/
Specialty
Ophthalmology
Adie syndrome, also known as Holmes–Adie syndrome, is a neurological disorder characterized by a tonically dilated pupil that reacts slowly to light but shows a more definite response to accommodation (i.e., light-near dissociation).[1] It is frequently seen in females with absent knee or ankle jerks and impaired sweating.
The syndrome is caused by damage to the postganglionic fibers of the parasympathetic innervation of the eye, usually by a viral or bacterial infection that causes inflammation, and affects the pupil of the eye and the autonomic nervous system.[1] It is named after the British neurologists William John Adie and Gordon Morgan Holmes, who independently described the same disease in 1931.[2]
^ ab"Holmes-Adie syndrome Information Page". National Institute of Neurological Disorders and Stroke. Archived from the original on 2007-10-16. Retrieved 2008-01-21.
^Siddiqui AA, Clarke JC, Grzybowski A (November 2014). "William John Adie: the man behind the syndrome" (PDF). Clinical & Experimental Ophthalmology. 42 (8): 778–84. doi:10.1111/ceo.12301. PMID 24533698.
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