Uveitis (/ˌjuːvi.aɪtɪs/) is inflammation of the uvea, the pigmented layer of the eye between the inner retina and the outer fibrous layer composed of the sclera and cornea.[1] The uvea consists of the middle layer of pigmented vascular structures of the eye and includes the iris, ciliary body, and choroid. Uveitis is described anatomically, by the part of the eye affected, as anterior, intermediate or posterior, or panuveitic if all parts are involved. Anterior uveitis (iridocyclitis) is the most common, with the incidence of uveitis overall affecting approximately 1:4500, most commonly those between the ages of 20-60. Symptoms include eye pain, eye redness, floaters and blurred vision, and ophthalmic examination may show dilated ciliary blood vessels and the presence of cells in the anterior chamber. Uveitis may arise spontaneously, have a genetic component, or be associated with an autoimmune disease or infection. While the eye is a relatively protected environment, its immune mechanisms may be overcome resulting in inflammation and tissue destruction associated with T-cell activation.
Uveitis is an ophthalmic emergency that requires urgent control of the inflammation to prevent vision loss. Treatment typically involves the use of topical eye drop steroids, intravitreal injection, newer biologics, and treating any underlying disease. While initial treatment is usually successful, complications include other ocular disorders, such as uveitic glaucoma, retinal detachment, optic nerve damage, cataracts, and in some cases, a permanent loss of vision. In the United States uveitis accounts for about 10%-20% of cases of blindness.
Anterior eye showing uveal structures (iris, ciliary body, with adjacent choroid which connects them)
^"Uveitis". National Eye Institute, US National Institutes of Health. 16 November 2021. Retrieved 19 April 2023.
panuveitic if all parts are involved. Anterior uveitis (iridocyclitis) is the most common, with the incidence of uveitis overall affecting approximately 1:4500...
Intermediate uveitis is a form of uveitis localized to the vitreous and peripheral retina. Primary sites of inflammation include the vitreous of which...
arthritis, and uveitis. Blau syndrome classically presents in early childhood as a triad of granulomatous dermatitis, arthritis, and uveitis. Arthritis typically...
disease may progress to severe inflammation of the uveal layer of the eye (uveitis) with pain and sensitivity of the eyes to light. The affected eye often...
Hollingsworth, SR (2016). "Chapter 8: Diseases of the uvea, uveitis and recurrent uveitis". In Gilger, BC (ed.). Equine Ophthalmology (3rd ed.). John...
Panuveitis also known as Diffuse uveitis or Total uveitis is an eye disease affecting the internal structures of the eye. In this inflammation occurs throughout...
Fuchs heterochromic iridocyclitis (FHI) is a chronic unilateral uveitis appearing with the triad of heterochromia, predisposition to cataract and glaucoma...
Uveitic glaucoma (or uveitis glaucoma, or anterior uveitic glaucoma, or anterior noninfectious uveitic glaucoma, or uveitis associated with glaucoma, or...
(phacoclastic uveitis). In one study, 45% of affected rabbits showed neurological deficits, 31% had renal symptoms, and 14% had uveitis. Outdoor rabbits...
fluctuation in IOP levels. Secondary glaucoma is commonly associated with uveitis. Uveitis is the inflammation of the uvea, a middle layer tissue of the eye consisting...
acetonide intravitreal implants have been used to treat non-infectious uveitis. A systematic review could not determine with any confidence whether fluocinolone...
front of the eye (specifically iridocyclitis, a form of chronic anterior uveitis), which affects about one in six children with JIA. Eye involvement occurs...
occurs Extra-articular features, such as involvement of eyes (anterior uveitis), skin, genitourinary tract, and aortic regurgitation Overlap is likely...
Tubulointerstitial nephritis and uveitis (TINU) is a rare medical condition in which there is uveitis (inflammation of the uvea in the eye) together with...
experience anterior uveitis causing eye pain, redness, and blurred vision. This is thought to be due to the association that both AS and uveitis have with the...
rhinitis. It is used for the treatment of macular edema associated with uveitis. It is a more potent derivative of triamcinolone, and is about eight times...
disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis. It is administered by subcutaneous injection (injection under the skin)...
epithelium. A slit lamp examination is likely to show evidence of anterior uveitis.[citation needed] Omics technologies have been used to identify biomarkers...
eye Uveitis – Inflammation of the uvea of the eye Huang, John H.; Gaudio, Paul A., eds. (2010). "Hypopyon". Ocular Inflammatory Disease and Uveitis: Diagnosis...
associated with ocular surgery; and the treatment of endogenous anterior uveitis. Difluprednate ophthalmic emulsion 0.05% is also being studied in other...
chorioretinopathy, now commonly named birdshot uveitis or HLA-A29 uveitis, is a rare form of bilateral posterior uveitis affecting both eyes. It causes severe...
common today with modern lens replacement techniques. Chronic uveitis and intermediate uveitis can be a cause. Blockage of a vein in the retina can cause...
traumatic brain injury (MTBI), or severe ophthalmologic diseases such as uveitis or corneal abrasion. A more extensive list follows: Causes of photophobia...
of panuveitis, and in children it is the most prevalent cause of both uveitis and panuveitis. The disease almost always affects only one eye. The first...
procedure is used in management of glaucoma and uveitis. It is also used for clinical diagnosis of infectious uveitis. Anterior chamber paracentesis is used in...
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