Acute myelomonocytic leukemia (AMML) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts. AMML occurs with a rapid increase amount in white blood cell count and is defined by more than 20% of myeloblast in the bone marrow. It is classified under "M4" in the French-American-British classification (FAB).[1] It is classified under "AML, not otherwise classified" in the WHO classification.[2]
Translocations have been observed.[3] Progression from myelodysplastic syndrome has been reported.[4]
^"Acute Myeloid Leukemia - Signs and Symptoms".
^"eMedicine - Acute Myelogenous Leukemia : Article by Karen Seiter". 7 May 2021.
^Yamamoto K, Nagata K, Tsurukubo Y, et al. (2002). "Translocation (8;12)(q13;p13) during disease progression in acute myelomonocytic leukemia with t(11;19)(q23;p13.1)". Cancer Genet. Cytogenet.137 (1): 64–7. doi:10.1016/S0165-4608(02)00555-1. PMID 12377416.
^Zhang L, Alsabeh R, Mecucci C, et al. (2007). "Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature". Cancer Genet. Cytogenet.178 (1): 42–8. doi:10.1016/j.cancergencyto.2007.06.012. PMID 17889707.
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