APC resistance test; Activated protein C resistance assay; APC resistance assay; APCR test; APCR assay
Test of
Activated protein C resistance, coagulation, hypercoagulability
The activated protein C resistance (APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form of hypercoagulability.[1][2] Hereditary APC resistance is usually caused by the factor V Leiden mutation, whereas acquired APC resistance has been linked to antiphospholipid antibodies, pregnancy, and estrogen therapy.[3][4][5][6] APC resistance can be measured using either an activated partial thromboplastin time (aPTT)-based test or an endogenous thrombin potential (ETP)-based test.[5][4][2]
^Amiral J, Vissac AM, Seghatchian J (December 2017). "Laboratory assessment of Activated Protein C Resistance/Factor V-Leiden and performance characteristics of a new quantitative assay". Transfus Apher Sci. 56 (6): 906–913. doi:10.1016/j.transci.2017.11.021. PMID 29162399.
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^Bremme KA (June 2003). "Haemostatic changes in pregnancy". Best Pract Res Clin Haematol. 16 (2): 153–68. doi:10.1016/s1521-6926(03)00021-5. PMID 12763484.
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