Overview of the acid peptic diseases of the stomach and gastrointestinal tract
Medical condition
Acid peptic diseases
Specialty
Gastroenterology
Acid peptic diseases, such as peptic ulcers, Zollinger-Ellison syndrome, and gastroesophageal reflux disease, are caused by distinct but overlapping pathogenic mechanisms involving acid effects on mucosal defense. Acid reflux damages the esophageal mucosa and may also cause laryngeal tissue injury, leading to the development of pulmonary symptoms.[1]
The pharmacologic treatment of acid peptic disorders centers on redressing this imbalance by either improving mucosal defenses with drugs like sucralfate, bismuth, and prostaglandin analogs, neutralizing acid with antacids, or decreasing acid secretion with histamine 2 receptor antagonists or, more recently, proton pump inhibitors.[2]
^Mejia, Alex; Kraft, Walter K (2009). "Acid peptic diseases: pharmacological approach to treatment". Expert Review of Clinical Pharmacology. 2 (3). Informa UK Limited: 295–314. doi:10.1586/ecp.09.8. ISSN 1751-2433. PMC 3149864. Retrieved November 6, 2023.
^Sanders, S (1996). "Pathogenesis and treatment of acid peptic disorders: comparison of proton pump inhibitors with other antiulcer agents". Clinical Therapeutics. 18 (1). Elsevier BV: 2–34. doi:10.1016/s0149-2918(96)80175-5. ISSN 0149-2918. Retrieved November 6, 2023.
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