MCOLN2 information

MCOLN2
Identifiers
Aliases	MCOLN2, TRP-ML2, TRPML2, mucolipin 2, mucolipin TRP cation channel 2
External IDs	OMIM: 607399; MGI: 1915529; HomoloGene: 12258; GeneCards: MCOLN2; OMA:MCOLN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	84,997,113 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,901,268 bp
RNA expression pattern
	Top expressed in
	tibia; ; cartilage tissue; ; rectum; ; mucosa of transverse colon; ; lymph node; ; right adrenal cortex; ; mucosa of ileum; ; granulocyte; ; left adrenal gland; ; secondary oocyte;
	Top expressed in
	Ileal epithelium; ; yolk sac; ; duodenum; ; spleen; ; stroma of bone marrow; ; mesenteric lymph nodes; ; jejunum; ; colon; ; embryo; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; cation channel activity; NAADP-sensitive calcium-release channel activity;
Cellular component	integral component of membrane; membrane; lysosome; lysosomal membrane; endosome; plasma membrane; late endosome membrane; recycling endosome membrane; recycling endosome;
Biological process	ion transport; adaptive immune response; immune system process; calcium ion transport; protein transport; innate immune response; calcium ion transmembrane transport; positive regulation of chemokine production; protein complex oligomerization; positive regulation of monocyte chemotactic protein-1 production; positive regulation of macrophage inflammatory protein 1 alpha production; positive regulation of chemokine (C-C motif) ligand 5 production; macrophage migration; neutrophil migration; positive regulation of chemokine (C-X-C motif) ligand 2 production; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	255231
	68279
	ENSG00000153898
	ENSMUSG00000011008
	Q8IZK6
	Q8K595
	NM_153259; NM_001330647
	NM_001005846; NM_026656
	NP_001317576; NP_694991
	NP_001005846; NP_080932
	Wikidata
View/Edit Human	View/Edit Mouse

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.^[5] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153898 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000011008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.
^ Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026. S2CID 25624298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153898 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000011008 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382100-5] Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.

[pmid17662026-6] Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic. 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026. S2CID 25624298.

MCOLN2 information

and 6 Related for: MCOLN2 information

MCOLN2

TRPML

Cation channel superfamily

Intracellular transport

MCOLN1

MCOLN3