CYTH4 information

CYTH4
Identifiers
Aliases	CYTH4, CYT4, DJ63G5.1, PSCD4, cytohesin 4, cytohesin-4
External IDs	OMIM: 606514 MGI: 2441702 HomoloGene: 22750 GeneCards: CYTH4
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,315,341 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,622,019 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; spleen; ; appendix; ; lymph node; ; periodontal fiber; ; bone marrow cells; ; gallbladder; ; right coronary artery; ; upper lobe of left lung;
	Top expressed in
	spleen; ; subcutaneous adipose tissue; ; blood; ; superior frontal gyrus; ; thymus; ; body of femur; ; esophagus; ; lip; ; white adipose tissue; ; cervix;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; lipid binding;
Cellular component	plasma membrane; membrane; Golgi membrane; cytosol;
Biological process	regulation of ARF protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27128
	72318
	ENSG00000100055
	ENSMUSG00000018008
	Q9UIA0
	Q80YW0
	NM_013385; NM_001318024
	NM_028195
	NP_001304953; NP_037517
	NP_082471
	Wikidata
View/Edit Human	View/Edit Mouse

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.^[5]^[6]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ ^a ^b "Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100055 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018008 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10591208-5] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-6] "Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4".

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