Discovery and development of bisphosphonates information

generation of bisphosphonates included etidronic acid and clodronic acid which were introduced in the 1970s and 1980s. They were the first bisphosphonate drugs...

intravenous bisphosphonates, with most cases being reported in cancer patients. Bone: alendronate has been linked in long-term users to the development of low-impact...

of the jaw (MRONJ), has been described as a side-effect of amino-bisphosphonates, a class of phosphorus-based drugs that inhibit bone resorption and are...

supports the use of medications of the bisphosphonate class, such as pamidronate, to increase bone density. Bisphosphonates are especially effective in children...

The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole". In Fischer J, Ganellin CR (eds.). Analogue-based drug discovery. Weinheim:...

As of 2013, high-quality evidence supports the use of bisphosphonates (either orally or via IV infusion) in the treatment of CRPS. Bisphosphonates inhibit...

removal and is active in the body for only six months. Similarly to bisphosphonates, denosumab appears to be implicated in increasing the risk of osteonecrosis...

Transactions of the Royal Society. 98: 1–44. doi:10.1098/rstl.1808.0001. Shaposhnik VA (2007). "History of the discovery of potassium and sodium (on the...

reduction of bone pain or improvements in quality of life. Bone-targeted agents (BTAs) including bisphosphonates and denosumab, can interrupt osteoclast-mediated...

effects of use of bisphosphonates which can cause osteochemonecrosis of the bone. The chance of further bleeding reduces as healing progresses, and is unlikely...

infection, Gaucher's disease, and Caisson disease (dysbaric osteonecrosis). Bisphosphonates are associated with osteonecrosis of the mandible (jawbone). The...

may vitamin D. When medication is used, it may include bisphosphonates, strontium ranelate, and osteoporosis may be one factor considered when commencing...

fibrosis, the evidence about the effectiveness of antibiotics for S. maltophilia is uncertain. Bisphosphonates taken by mouth or intravenously can be used...

effect of bisphosphonates on BMD did not provide significant evidence of improvement, and the scope of studies are inadequate to ensure safety and efficacy...

of use, the cell became known by its present name. Giant osteoclasts can occur in some diseases, including Paget's disease of bone and bisphosphonate...

denosumab and the bisphosphonates; infusion every three months reduces the chance of bone pain, fractures, and bone hypercalcemia. Up to 70% of those with ER-positive...

survival rates. Use of bisphosphonates appears to significantly increase survival. Etidronate, a non-nitrogen-containing bisphosphonate, is the most commonly...

anti-inflammatory drugs (e.g., ibuprofen), bisphosphonates, and other chemotherapeutic agents such as melphalan, interleukin 2, and anthracyclines. Other medications...

of calcium, vitamin D, and bisphosphonates. Inadequate amounts of calcium, vitamin D, or phosphates can lead to softening of bones, called osteomalacia...

prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. For osteoporosis it is less preferred than bisphosphonates. It is...

Fry, C.; Thoennessen, M. (2013). "Discovery of the astatine, radon, francium, and radium isotopes". Atomic Data and Nuclear Data Tables. 09 (5): 497–519...

identified as a key mediator of the effects of statins and bisphosphonates on bone, muscle, and macrophages. On the basis of these findings, it has been...

the first year of infection. Prodrome precedes development of lesions. Prodromal symptoms include tingling (paresthesia), itching, and pain where lumbosacral...

(TMDs): From Research Discoveries to Clinical Treatment; Board on Health Sciences Policy; Board on Health Care Services; Health and Medicine Division; National...