YY1 information

YY1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UBD, 1ZNM, 4C5I
Identifiers
Aliases	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
External IDs	OMIM: 600013; MGI: 99150; HomoloGene: 2556; GeneCards: YY1; OMA:YY1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	100,282,788 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	108,786,074 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; rectum; ; monocyte; ; tonsil; ; sural nerve; ; skin of thigh;
	Top expressed in
	medullary collecting duct; ; primitive streak; ; ureter; ; renal corpuscle; ; Gonadal ridge; ; abdominal wall; ; left lung lobe; ; cumulus cell; ; human fetus; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; transcription coactivator activity; zinc ion binding; metal ion binding; protein binding; four-way junction DNA binding; cis-regulatory region sequence-specific DNA binding; RNA binding; nucleic acid binding; SMAD binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding;
Cellular component	Ino80 complex; nuclear matrix; nucleus; nucleoplasm; transcription regulator complex; cytoplasm; PcG protein complex;
Biological process	cell differentiation; DNA recombination; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; cellular response to UV; negative regulation of gene expression; transcription, DNA-templated; cellular response to DNA damage stimulus; double-strand break repair via homologous recombination; spermatogenesis; DNA repair; protein deubiquitination; negative regulation of interferon-beta production; negative regulation of transcription by RNA polymerase II; RNA localization; anterior/posterior pattern specification; response to UV-C; positive regulation of gene expression; response to prostaglandin F; positive regulation of transcription by RNA polymerase II; camera-type eye morphogenesis; chromosome organization; cellular response to interleukin-1; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of cell growth involved in cardiac muscle cell development;
	Sources:Amigo / QuickGO
Orthologs
	7528
	22632
	ENSG00000100811
	ENSMUSG00000021264
	P25490
	Q00899
	NM_003403
	NM_009537
	NP_003394
	NP_033563
	Wikidata
View/Edit Human	View/Edit Mouse

YY1 (Yin Yang 1)^[5] is a transcriptional repressor protein in humans that is encoded by the YY1 gene.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100811 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.
^ Shi Y, Seto E, Chang LS, Shenk T (October 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. S2CID 19399858.
^ Zhu W, Lossie AC, Camper SA, Gumucio DL (April 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122. S2CID 27296553.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100811 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021264 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Thiaville MM, Kim J (2011). "Oncogenic potential of yin yang 1 mediated through control of imprinted genes". Critical Reviews in Oncogenesis. 16 (3–4): 199–209. doi:10.1615/critrevoncog.v16.i3-4.40. PMC 3392609. PMID 22248054.

[pmid1655281-6] Shi Y, Seto E, Chang LS, Shenk T (October 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. doi:10.1016/0092-8674(91)90189-6. PMID 1655281. S2CID 19399858.

[pmid7912122-7] Zhu W, Lossie AC, Camper SA, Gumucio DL (April 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. doi:10.1007/BF00360552. hdl:2027.42/47010. PMID 7912122. S2CID 27296553.

YY1 information

and 16 Related for: YY1 information

YY1

RYBP

LINE1

Regulatory sequence

Myc

Transcriptional regulation

YAF2

List of human transcription factors

YY1AP1

Short interspersed nuclear element

Eric Walter Elst

Histone deacetylase

Gene expression

Histone deacetylase inhibitor

Notch 1

Homeobox