XRCC3 information

XRCC3
Identifiers
Aliases	XRCC3, CMM6, X-ray repair complementing defective repair in Chinese hamster cells 3, X-ray repair cross complementing 3
External IDs	OMIM: 600675; MGI: 1921585; HomoloGene: 36178; GeneCards: XRCC3; OMA:XRCC3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,715,504 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,780,307 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; canal of the cervix; ; right uterine tube; ; ectocervix; ; right coronary artery; ; tibial nerve; ; apex of heart; ; right ovary; ; body of uterus; ; left ovary;
	Top expressed in
	yolk sac; ; zygote; ; primary oocyte; ; genital tubercle; ; secondary oocyte; ; lumbar subsegment of spinal cord; ; Paneth cell; ; tail of embryo; ; lip; ; hand;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	crossover junction endodeoxyribonuclease activity; nucleotide binding; DNA binding; ATP-dependent activity, acting on DNA; DNA strand exchange activity; single-stranded DNA binding; protein binding; four-way junction DNA binding; double-stranded DNA binding; ATP binding;
Cellular component	cytoplasm; replication fork; nucleoplasm; Rad51C-XRCC3 complex; mitochondrion; perinuclear region of cytoplasm; Rad51B-Rad51C-Rad51D-XRCC2 complex; nucleus; cytosol;
Biological process	strand invasion; response to ionizing radiation; positive regulation of mitotic cell cycle spindle assembly checkpoint; reciprocal meiotic recombination; DNA recombination; regulation of centrosome duplication; resolution of mitotic recombination intermediates; response to organic substance; cellular response to DNA damage stimulus; telomere maintenance via recombination; t-circle formation; DNA repair; meiotic DNA recombinase assembly; interstrand cross-link repair; double-strand break repair via homologous recombination; telomeric loop disassembly; telomere maintenance via telomere trimming; double-strand break repair via synthesis-dependent strand annealing;
	Sources:Amigo / QuickGO
Orthologs
	7517
	74335
	ENSG00000126215
	ENSMUSG00000021287
	O43542
	Q9CXE6
NM_001100118; NM_001100119; NM_005432; NM_001371229; NM_001371231;
	NM_001371232
	NM_028875
NP_001093588; NP_001093589; NP_005423; NP_001358158; NP_001358160;
	NP_001358161
	NP_083151
	Wikidata
View/Edit Human	View/Edit Mouse

DNA repair protein XRCC3 is a protein that in humans is encoded by the XRCC3 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000126215 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021287 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tebbs RS, Zhao Y, Tucker JD, Scheerer JB, Siciliano MJ, Hwang M, Liu N, Legerski RJ, Thompson LH (August 1995). "Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene". Proc Natl Acad Sci U S A. 92 (14): 6354–6358. Bibcode:1995PNAS...92.6354T. doi:10.1073/pnas.92.14.6354. PMC 41516. PMID 7603995.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000126215 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021287 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7603995-5] Tebbs RS, Zhao Y, Tucker JD, Scheerer JB, Siciliano MJ, Hwang M, Liu N, Legerski RJ, Thompson LH (August 1995). "Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene". Proc Natl Acad Sci U S A. 92 (14): 6354–6358. Bibcode:1995PNAS...92.6354T. doi:10.1073/pnas.92.14.6354. PMC 41516. PMID 7603995.

XRCC3 information

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