UQCRQ information

UQCRQ
Identifiers
Aliases	UQCRQ, MC3DN4, QCR8, QP-C, QPC, UQCR7, ubiquinol-cytochrome c reductase complex III subunit VII
External IDs	OMIM: 612080; MGI: 107807; HomoloGene: 40942; GeneCards: UQCRQ; OMA:UQCRQ - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,868,847 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,321,658 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; body of tongue; ; left ventricle; ; renal medulla; ; mucosa of transverse colon; ; vena cava; ; lateral nuclear group of thalamus; ; mucosa of pharynx; ; right auricle; ; gastrocnemius muscle;
	Top expressed in
	interventricular septum; ; choroid plexus of fourth ventricle; ; right kidney; ; plantaris muscle; ; muscle of thigh; ; Ileal epithelium; ; extensor digitorum longus muscle; ; cardiac muscle tissue of left ventricle; ; soleus muscle; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquinol-cytochrome-c reductase activity;
Cellular component	mitochondrial inner membrane; respirasome; mitochondrion; membrane; mitochondrial respiratory chain complex III;
Biological process	pons development; pyramidal neuron development; hippocampus development; cerebellar Purkinje cell layer development; midbrain development; thalamus development; hypothalamus development; subthalamus development; mitochondrial electron transport, ubiquinol to cytochrome c;
	Sources:Amigo / QuickGO
Orthologs
	27089
	22272
	ENSG00000164405
	ENSMUSG00000044894
	O14949
	Q9CQ69
	NM_014402
	NM_025352; NM_001326614
	NP_055217
	NP_001313543; NP_079628
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa is a protein that in humans is encoded by the UQCRQ gene. This ubiqinone-binding protein is a subunit of mitochondrial Complex III in the electron transport chain.^[5] A mutation in the UQCRQ gene has been shown to cause severe neurological disorders.^[6] Infection by Trypanosoma cruzi can cause oxidative modification of this protein in cardiac muscle tissue.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044894 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference :0 was invoked but never defined (see the help page).
^ Barel O, Shorer Z, Flusser H, Ofir R, Narkis G, Finer G, Shalev H, Nasasra A, Saada A, Birk OS (May 2008). "Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ". American Journal of Human Genetics. 82 (5): 1211–6. doi:10.1016/j.ajhg.2008.03.020. PMC 2427202. PMID 18439546.
^ Wen JJ, Garg N (December 2004). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radical Biology & Medicine. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044894 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Cite error: The named reference :0 was invoked but never defined (see the help page).

[:1-6] Barel O, Shorer Z, Flusser H, Ofir R, Narkis G, Finer G, Shalev H, Nasasra A, Saada A, Birk OS (May 2008). "Mitochondrial complex III deficiency associated with a homozygous mutation in UQCRQ". American Journal of Human Genetics. 82 (5): 1211–6. doi:10.1016/j.ajhg.2008.03.020. PMC 2427202. PMID 18439546.

[:2-7] Wen JJ, Garg N (December 2004). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radical Biology & Medicine. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.

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