Viral metagenomics uses metagenomic technologies to detect viral genomic material from diverse environmental and clinical samples.[1][2] Viruses are the most abundant biological entity and are extremely diverse; however, only a small fraction of viruses have been sequenced and only an even smaller fraction have been isolated and cultured.[1][3] Sequencing viruses can be challenging because viruses lack a universally conserved marker gene so gene-based approaches are limited.[3][4] Metagenomics can be used to study and analyze unculturable viruses and has been an important tool in understanding viral diversity and abundance and in the discovery of novel viruses.[1][5][6] For example, metagenomics methods have been used to describe viruses associated with cancerous tumors and in terrestrial ecosystems.[7]
^ abcSommers P, Chatterjee A, Varsani A, Trubl G (September 2021). "Integrating Viral Metagenomics into an Ecological Framework". Annual Review of Virology. 8 (1): 133–158. doi:10.1146/annurev-virology-010421-053015. PMID 34033501.
^Grasis JA (2018). "Host-Associated Bacteriophage Isolation and Preparation for Viral Metagenomics". Viral Metagenomics. Methods in Molecular Biology. Vol. 1746. New York, NY: Springer New York. pp. 1–25. doi:10.1007/978-1-4939-7683-6_1. ISBN 978-1-4939-7682-9. PMID 29492882. S2CID 3637163. Retrieved 2022-12-02.
^ abKrishnamurthy SR, Wang D (July 2017). "Origins and challenges of viral dark matter". Virus Research. 239: 136–142. doi:10.1016/j.virusres.2017.02.002. PMID 28192164.
^Pappas N, Roux S, Hölzer M, Lamkiewicz K, Mock F, Marz M, Dutilh BE (2021). "Virus Bioinformatics". In Bamford DH, Zuckerman M (eds.). Encyclopedia of Virology (4th ed.). Elsevier. pp. 124–132. doi:10.1016/b978-0-12-814515-9.00034-5. ISBN 978-0-12-814516-6. PMC 7567488.
^Kristensen DM, Mushegian AR, Dolja VV, Koonin EV (January 2010). "New dimensions of the virus world discovered through metagenomics". Trends in Microbiology. 18 (1): 11–19. doi:10.1016/j.tim.2009.11.003. PMC 3293453. PMID 19942437.
^Bernardo P, Albina E, Eloit M, Roumagnac P (May 2013). "[Pathology and viral metagenomics, a recent history]". Médecine/Sciences (in French). 29 (5): 501–508. doi:10.1051/medsci/2013295013. PMID 23732099.
^Alavandi SV, Poornima M (September 2012). "Viral metagenomics: a tool for virus discovery and diversity in aquaculture". Indian Journal of Virology. 23 (2): 88–98. doi:10.1007/s13337-012-0075-2. PMC 3550753. PMID 23997432.
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