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Vertebrate Genome Annotation Project information


The Vertebrate Genome Annotation (VEGA) database is a biological database dedicated to assisting researchers in locating specific areas of the genome and annotating genes or regions of vertebrate genomes.[1] The VEGA browser is based on Ensembl web code and infrastructure and provides a public curation of known vertebrate genes for the scientific community.[2][3] The VEGA website is updated frequently to maintain the most current information about vertebrate genomes and attempts to present consistently high-quality annotation of all its published vertebrate genomes or genome regions.[4] VEGA was developed by the Wellcome Trust Sanger Institute and is in close association with other annotation databases, such as ZFIN (The Zebrafish Information Network), the Havana Group and GenBank.[1][5] Manual annotation is currently more accurate at identifying splice variants, pseudogenes, polyadenylation features, non-coding regions and complex gene arrangements than automated methods.[5]

  1. ^ a b "Vega Genome Browser". Wellcome Sanger Institute. Retrieved 30 October 2012.
  2. ^ Searle, S. M.J.; Gilbert, J; Iyer, V; Clamp, M (1 May 2004). "The Otter Annotation System". Genome Research. 14 (5): 963–970. doi:10.1101/gr.1864804. PMC 479127. PMID 15123593.
  3. ^ Hubbard, T.; Barker, D; Birney, E; Cameron, G; Chen, Y; Clark, L; Cox, T; Cuff, J; Curwen, V (1 January 2002). "The Ensembl genome database project". Nucleic Acids Research. 30 (1): 38–41. doi:10.1093/nar/30.1.38. PMC 99161. PMID 11752248.
  4. ^ Loveland, J. (1 January 2005). "VEGA, the genome browser with a difference". Briefings in Bioinformatics. 6 (2): 189–193. doi:10.1093/bib/6.2.189. PMID 15975227.
  5. ^ a b Ashurst, J. L.; Chen, CK; Gilbert, JG; Jekosch, K; Keenan, S; Meidl, P; Searle, SM; Stalker, J; Storey, R (17 December 2004). "The Vertebrate Genome Annotation (Vega) database". Nucleic Acids Research. 33 (Database issue): D459–D465. doi:10.1093/nar/gki135. PMC 540089. PMID 15608237.

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