VPS4A information

VPS4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YXR, 2JQ9, 2K3W
Identifiers
Aliases	VPS4A, SKD1, SKD1A, SKD2, VPS4, VPS4-1, vacuolar protein sorting 4 homolog A, CIMDAG
External IDs	OMIM: 609982 MGI: 1890520 HomoloGene: 69132 GeneCards: VPS4A
Gene location (Human)
Chr.	Chromosome 16 (human)
End	69,326,939 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	107,772,387 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; cerebellar vermis; ; parotid gland; ; Brodmann area 23; ; middle temporal gyrus; ; endothelial cell; ; triceps brachii muscle; ; body of pancreas; ; inferior olivary nucleus; ; quadriceps femoris muscle;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; dorsal tegmental nucleus; ; superior colliculus; ; pontine nuclei; ; medial dorsal nucleus; ; subiculum; ; cerebellar cortex; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein domain specific binding; microtubule-severing ATPase activity; protein C-terminus binding; protein binding; hydrolase activity; ATP binding; ATPase activity; protein-containing complex binding;
Cellular component	cytoplasm; ESCRT III complex; cytosol; endosome; late endosome; centrosome; spindle pole; vacuolar membrane; late endosome membrane; Flemming body; membrane; plasma membrane; midbody; early endosome; perinuclear region of cytoplasm; lysosome; extracellular exosome; nucleus; endosome membrane;
Biological process	late endosomal microautophagy; endosomal vesicle fusion; viral release from host cell; abscission; viral budding via host ESCRT complex; nucleus organization; viral life cycle; multivesicular body assembly; vacuole organization; vesicle uncoating; regulation of protein localization; cell division; intracellular cholesterol transport; ESCRT complex disassembly; vesicle budding from membrane; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; transport; protein transport; positive regulation of viral life cycle; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; cell cycle; negative regulation of cytokinesis; septum digestion after cytokinesis; mitotic metaphase plate congression; positive regulation of exosomal secretion; vesicle-mediated transport; regulation of protein localization to plasma membrane; ESCRT III complex disassembly; cytoplasmic microtubule organization; endosomal transport; macroautophagy; positive regulation of viral budding via host ESCRT complex; actomyosin contractile ring contraction; protein targeting to lysosome; nuclear envelope organization; nuclear membrane reassembly; mitotic cytokinesis checkpoint signaling; cytoskeleton-dependent cytokinesis; midbody abscission;
	Sources:Amigo / QuickGO
Orthologs
	27183
	116733
	ENSG00000132612
	ENSMUSG00000031913
	Q9UN37
	Q8VEJ9
	NM_013245
	NM_126165
	NP_037377; NP_037377.1
	NP_569053
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting-associated protein 4A is a protein that in humans is encoded by the VPS4A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132612 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031913 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bishop N, Woodman P (April 2000). "ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking". Mol Biol Cell. 11 (1): 227–39. doi:10.1091/mbc.11.1.227. PMC 14770. PMID 10637304.
^ Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF, Köhrer K (September 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
^ "Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132612 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031913 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10637304-5] Bishop N, Woodman P (April 2000). "ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking". Mol Biol Cell. 11 (1): 227–39. doi:10.1091/mbc.11.1.227. PMC 14770. PMID 10637304.

[pmid11563910-6] Scheuring S, Röhricht RA, Schöning-Burkhardt B, Beyer A, Müller S, Abts HF, Köhrer K (September 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.

[entrez-7] "Entrez Gene: VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)".

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