ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
protein transport
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
positive regulation of G2/M transition of mitotic cell cycle
positive regulation of exosomal secretion
septum digestion after cytokinesis
mitotic metaphase plate congression
endosome to lysosome transport via multivesicular body sorting pathway
cell cycle
ESCRT III complex disassembly
macroautophagy
transport
positive regulation of viral process
vacuole organization
midbody abscission
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9525
20479
Ensembl
ENSG00000119541
ENSMUSG00000009907
UniProt
O75351
P46467
RefSeq (mRNA)
NM_004869
NM_009190
RefSeq (protein)
NP_004860 NP_004860.2
NP_033216
Location (UCSC)
Chr 18: 63.39 – 63.42 Mb
Chr 1: 106.69 – 106.72 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.[5][6]
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.
In humans, two paralogs of the yeast protein have been identified. They share a high degree of amino acid sequence similarity with each other and also with yeast Vps4 and mouse proteins. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other (VPS4A) resides on chromosome 16.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000119541 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000009907 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
^ ab"Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)".
sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene. The protein encoded by this gene is a member of the AAA protein family...
mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J Cell Sci. 117 (Pt 14): 2997–3009. doi:10.1242/jcs.01170. PMID 15173323...
mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B". J. Cell Sci. 117 (Pt 14): 2997–3009. doi:10.1242/jcs.01170. PMID 15173323...