positive regulation of collagen biosynthetic process
G protein-coupled receptor signaling pathway
negative regulation of histone deacetylation
activation of protein kinase A activity
response to estradiol
positive regulation of protein phosphorylation
associative learning
startle response
gastric emptying
negative regulation of blood pressure
female pregnancy
negative regulation of gastric acid secretion
negative regulation of apoptotic process
response to glucocorticoid
hearing
pancreatic juice secretion
response to oxidative stress
negative regulation of appetite
positive regulation of translation
negative regulation of gene expression
negative regulation of cell death
positive regulation of peptidyl-serine phosphorylation
positive regulation of DNA replication
aerobic respiration
positive regulation of calcium ion import
positive regulation of cell growth
positive regulation of vascular permeability
positive regulation of gene expression
drinking behavior
response to pain
positive regulation of cardiac muscle contraction
feeding behavior
positive regulation of interleukin-6 production
response to auditory stimulus
learning or memory
social behavior
regulation of synaptic transmission, glutamatergic
inflammatory response
neuropeptide signaling pathway
neuron projection development
negative regulation of necrotic cell death
positive regulation of behavioral fear response
negative regulation of cell size
positive regulation of transcription by RNA polymerase II
negative regulation of neuron death
negative regulation of hormone secretion
negative regulation of feeding behavior
regulation of signaling receptor activity
positive regulation of cAMP-mediated signaling
positive regulation of corticotropin secretion
negative regulation of epinephrine secretion
positive regulation of cortisol secretion
negative regulation of glucagon secretion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7349
22226
Ensembl
ENSG00000163794
ENSMUSG00000038676
UniProt
P55089
P81615
RefSeq (mRNA)
NM_003353
NM_021290 NM_001346010
RefSeq (protein)
NP_003344
NP_001332939 NP_067265
Location (UCSC)
Chr 2: 27.31 – 27.31 Mb
Chr 5: 31.3 – 31.3 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Urocortin is a protein that in humans is encoded by the UCN gene. Urocortin belongs to the corticotropin-releasing factor (CRF) family of proteins which includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is involved in the mammalian stress response, and regulates aspects of appetite and stress response.[5][6][7]
^ abcGRCh38: Ensembl release 89: ENSG00000163794 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038676 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhao L, Donaldson CJ, Smith GW, Vale WW (May 1998). "The structures of the mouse and human urocortin genes (Ucn and UCN)". Genomics. 50 (1): 23–33. doi:10.1006/geno.1998.5292. PMID 9628819.
^Tsarev OB (July 1977). "[Dynamics of matrix synthesis in molecular biophysics. II. Principle of insertability and the single-valued solution of feedback tasks]". Biofizika. 22 (2): 197–200. PMID 861256.
Urocortin is a protein that in humans is encoded by the UCN gene. Urocortin belongs to the corticotropin-releasing factor (CRF) family of proteins which...
Urocortin III, a 38–41 amino acid peptide, is a member of the CRF (corticotropin-releasing factor), also known as CRH (corticotropin-releasing hormone)...
Urocortin 2 (Ucn2) is an endogenous peptide in the corticotrophin-releasing factor (CRF) family. Urocortin II is a 38-amino acid peptide that is a member...
Urocortin-3 is a protein that, in humans, is encoded by the UCN3 gene. It belongs to the corticotropin-releasing hormone family. This gene is a member...
corticotropin-releasing factor (CRF) family that also includes CRF, urocortin l/urotensin l, urocortin II and urocortin III. Sauvagine has been shown to interact with corticotropin...
observed inside the islets as well. In both species, the peptide hormone Urocortin III (Ucn3) is a major local signal that is released from beta cells (and...
"Neuropeptide Regulation of Stress-Induced Behavior: Insights from the CRF/Urocortin Family". Handbook of Neuroendocrinology. Academic Press. pp. 355–375....
Urocortin-2 is a protein that in humans is encoded by the UCN2 gene. This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I...
SW, Perrin MH, et al. (1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5): 2167–70. doi:10.1210/endo.137.5.8612563. PMID 8612563...
Union (Bolivia), a political party Ultracold neutrons Genes in the human urocortin family UCN (gene) UCN2 UCN3 UCN, the IATA Airport Code for Buchanan Airport...
permeability and mast cell degranulation response induced by intradermal Urocortin (10 nM). Collectively, these results indicate that during stress, CRH...