UCN2 information

UCN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RMG, 3N95
Identifiers
Aliases	UCN2, SRP, UCN-II, UCNI, UR, URP, urocortin 2
External IDs	OMIM: 605902; MGI: 2176375; HomoloGene: 50048; GeneCards: UCN2; OMA:UCN2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	48,563,781 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,816,232 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; testicle; ; skin of abdomen; ; skin of leg; ; olfactory zone of nasal mucosa; ; vagina; ; prostate; ; minor salivary glands; ; ectocervix; ; tibial nerve;
	Top expressed in
	saccule; ; otic vesicle; ; otic placode; ; blastocyst; ; embryo; ; muscle of thigh; ; morula; ; esophagus; ; lip; ; skin of external ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone binding; G protein-coupled receptor binding; corticotropin-releasing hormone receptor 2 binding; hormone activity; corticotropin-releasing hormone receptor binding;
Cellular component	extracellular region; extracellular space; intracellular anatomical structure;
Biological process	digestion; cellular response to nutrient levels; regulation of signaling receptor activity; response to stress; adenylate cyclase-activating G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	90226
	171530
	ENSG00000145040
	ENSMUSG00000049699
	Q96RP3
	Q99ML8
	NM_033199
	NM_145077
	NP_149976
	NP_659543
	Wikidata
View/Edit Human	View/Edit Mouse

Urocortin-2 is a protein that in humans is encoded by the UCN2 gene.^[5]^[6]

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145040 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. S2CID 22916906.
^ ^a ^b "Entrez Gene: UCN2 urocortin 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145040 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049699 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11329063-5] Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. S2CID 22916906.

[entrez-6] "Entrez Gene: UCN2 urocortin 2".

UCN2 information

and 6 Related for: UCN2 information

UCN2

Urocortin II

Urocortin III

Chromosome 3

UCN

GNRHR2